AB34176

FITC Anti-Integrin alpha 1 antibody [TS2/7]

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(4 제품이 사용된 논문 )

Anti-Integrin alpha 1 antibody [TS2/7] conjugated to FITC - suitable for flow cytometry, and reacts with human samples. Clone [TS2/7] is a mouse monoclonal antibody cited in 48 publications.

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Flow Cytometry - FITC Anti-Integrin alpha 1 antibody [TS2/7] (AB34176)

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-Integrin alpha 1 antibody [TS2/7] (AB34176)

Flow Cytometry analysis of HeLa cells labeling Integrin alpha 1 with ab34176.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

TS2/7

Isotype

IgG1

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing ITGA1 protein. The exact immunogen used to generate this antibody is proprietary information.

P56199

Specificity

This antibody recognises the human alpha 1 integrin subunit.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/1 - 1/5", "FlowCyt-species-notes": "<p><a href='/ko/products/primary-antibodies/fitc-mouse-igg1-b11-6-isotype-control-ab91356'>ab91356</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

보관 버퍼

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 1 also called CD49a is a protein that functions as a mechanical link between cells and the extracellular matrix. It is part of the integrin protein family and partners with beta 1 integrin to form the integrin alpha 1 beta 1 complex. This protein is a heterodimer and weighs approximately 180 kDa. The integrin alpha 1 is expressed in various tissues including the dermis cartilage and the immune system especially on activated T cells and natural killer cells.

Biological function summary

Integrin alpha 1 beta 1 mediates cell adhesion and migration. It plays an important role in collagen binding influencing various cellular processes like proliferation and differentiation. Integrin alpha 1 forms a complex with ligand molecules notably collagen which assists in remodeling the extracellular matrix. This activity contributes to the development and repair of tissues offering structural support and pathways for cell signaling events.

Pathways

Integrin alpha 1 engages in the MAPK signaling pathway and regulation of the TGF-beta signaling cascade. By mediating interactions between cells and their environment it influences downstream signaling and gene expression. Integrins including integrin alpha 1 have roles in pathways related to cellular stress responses and signal modulation interacting with proteins such as fibronectin within these processes.

Integrin alpha 1 has been linked to fibrosis and chronic inflammatory diseases. By modulating matrix-related signals it influences the pathology of fibrosis through upregulation of matrix metalloproteinases. In chronic inflammatory diseases its interaction with collagen and other matrix proteins can affect immune cell trafficking and signaling. Understanding these connections helps in exploring potential therapeutic targets and interventions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

See full target information ITGA1

대체 명칭 보기

CD49a, Integrin alpha-1, CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, ITGA1

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 16:6870 PubMed40715114

2025

Mammalian cells measure the extracellular matrix area and respond through switching the adhesion state.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaole Wang,Pengli Wang,Lihang Zhang,Tianyu Xu,Seungkuk Ahn,Upnishad Sharma,Han Yu,Nico Strohmeyer,Daniel J Müller

Antioxidants (Basel, Switzerland) 11: PubMed36139739

2022

AMPK-Nrf2 Signaling Pathway in Phrenic Motoneurons following Cervical Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Pauline Michel-Flutot,Laurie Efthimiadi,Lynda Djerbal,Therese B Deramaudt,Marcel Bonay,Stéphane Vinit

Annals of the rheumatic diseases 69:270-5 PubMed19279017

2009

Transforming growth factor beta1 and laminin-111 cooperate in the induction of interleukin-16 expression in synovial fibroblasts from patients with rheumatoid arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

K Warstat,M Hoberg,M Rudert,S Tsui,T Pap,B Angres,M Essl,T J Smith,W W Cruikshank,G Klein,S Gay,W K Aicher

The Journal of biological chemistry 280:13848-57 PubMed15647274

2005

A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Joseph O Humtsoe,Jiyeun K Kim,Yi Xu,Douglas R Keene,Magnus Höök,Slawomir Lukomski,Kishore K Wary

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

FITC Anti-Integrin alpha 1 antibody [TS2/7]

Flow Cytometry - FITC Anti-Integrin alpha 1 antibody [TS2/7] (AB34176)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Immunogen

Specificity

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (4)

Product promise