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AB35035

FITC Anti-NKG2D antibody [1D11]

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(2 제품이 사용된 논문 )

Anti-NKG2D antibody [1D11] conjugated to FITC - suitable for flow cytometry, and reacts with human samples. Clone [1D11] is a mouse monoclonal antibody and one of the most commonly used clones for flow cytometry.

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관련 conjugated 항체와 다양한 조성의 항체 (3)

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

1D11

Isotype

IgG1

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing KLRK1 protein. The exact immunogen used to generate this antibody is proprietary information.

P26718

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대체품

Primary Antibodies

AB192524

Anti-NKG2D antibody

  • 0
  • 0
Primary Antibodies

AB203353

Anti-NKG2D antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NKG2D antibody (AB203353)

  • 3
  • 1
Primary Antibodies

AB35033

Anti-NKG2D antibody [1D11]

Flow Cytometry - Anti-NKG2D antibody [1D11] (AB35033)

  • 1
  • 1
Primary Antibodies

AB36136

Anti-NKG2D antibody

Flow Cytometry - Anti-NKG2D antibody (AB36136)

  • 0
  • 0
Primary Antibodies

AB89807

Anti-NKG2D antibody [MM0489-10R27]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NKG2D antibody [MM0489-10R27] (AB89807)

  • 0
  • 0

보완 제품

Assay Kits

AB314830

Human CD314 ELISA Kit

Sandwich ELISA - Human CD314 ELISA Kit (AB314830)

  • 0
  • 0
Primary Antibodies

AB237456

Alexa Fluor® 647 Anti-NCAM1 antibody [EP2567Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-NCAM1 antibody [EP2567Y] (AB237456)

  • 0
  • 0
Primary Antibodies

AB310299

Alexa Fluor® 647 Anti-CD16 antibody [SP175]

RabMAb|Recombinant

  • 0
  • 0
Primary Antibodies

AB305048

Alexa Fluor® 647 Anti-CD8 alpha antibody [CAL66]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD8 alpha antibody [CAL66] (AB305048)

  • 5
  • 1
Primary Antibodies

AB200315

Alexa Fluor® 488 Anti-CD45 antibody [EP322Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-CD45 antibody [EP322Y] (AB200315)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/ko/products/primary-antibodies/fitc-mouse-igg1-b11-6-isotype-control-ab91356'>ab91356</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }
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제품 세부 정보

Spleen cells from immunised RBF/DnJ mice were fused with cells of the p3 mouse myeloma cell line.
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
보관 버퍼
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NKG2D also known as natural killer group 2 member D is a type-2 transmembrane receptor with a mass of approximately 42 kDa. Expressed primarily on natural killer (NK) cells CD8+ T cells subsets of CD4+ T cells and some macrophages it recognizes stress-induced ligands presented on target cells. This protein plays an important role in the immune system's recognition and elimination of infected or transformed cells by binding to its ligands which include MHC class I chain-related proteins MICA/B and UL16-binding proteins.
Biological function summary

NKG2D acts as an activating receptor on the cell surface that initiates immune responses leading to cytotoxicity against target cells. It functions as part of a complex involving the adaptor protein DAP10 which transduces activating signals to promote cellular immune responses. This interaction amplifies the activation of immune cells and contributes to the host's defense against tumors and virally infected cells.

Pathways

NKG2D plays a significant role in immune surveillance and signaling pathways. It actively involves in the natural killer (NK) cell-mediated cytotoxicity pathway and the adaptive immune response pathway. The interaction with proteins such as DAP10 is critical for its signaling function contributing to its interaction within these pathways. The signaling through NKG2D directly affects the activation states and responses of immune cells which are vital in immune defense.

NKG2D is implicated in cancer and autoimmune diseases. In cancer overexpression of its ligands on tumor cells makes them susceptible to NKG2D-mediated cell lysis. On the other hand aberrant expression of NKG2D ligands in autoimmune disorders can lead to inappropriate immune activation. The interaction with MICA/B proteins is significant in these conditions emphasizing its importance in both immune surveillance and potential disease pathogenesis.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
See full target information KLRK1

대체 명칭 보기

CD314, D12S2489E, NKG2D, KLRK1, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncoimmunology 6:e1339854 PubMed28932639

2017

Soluble NKG2D ligands in the ovarian cancer microenvironment are associated with an adverse clinical outcome and decreased memory effector T cells independent of NKG2D downregulation.

Applications

Flow Cyt

Species

Human

Maulik Vyas,Silke Reinartz,Nathalie Hoffmann,Katrin S Reiners,Sonja Lieber,Julia M Jansen,Uwe Wagner,Rolf Müller,Elke Pogge von Strandmann

Molecular therapy : the journal of the American So 21:895-903 PubMed23459515

2013

Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patients.

Applications

Flow Cyt

Species

Human

Katrin S Reiners,Jörg Kessler,Maike Sauer,Achim Rothe,Hinrich P Hansen,Uwe Reusch,Christian Hucke,Ulrike Köhl,Horst Dürkop,Andreas Engert,Elke Pogge von Strandmann
제품이 사용된 논문 모두 보기
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Product promise

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