AB237528

Anti-FKBP11 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal FKBP11 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FKBP11 aa 1-200.

대체 명칭 보기

FKBP19, UNQ336/PRO535, FKBP11, Peptidyl-prolyl cis-trans isomerase FKBP11, PPIase FKBP11, 19 kDa FK506-binding protein, FK506-binding protein 11, Rotamase, 19 kDa FKBP, FKBP-19, FKBP-11

3 이미지

Immunocytochemistry/ Immunofluorescence - Anti-FKBP11 antibody (AB237528)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FKBP11 antibody (AB237528)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for FKBP11 using ab237528 at a dilution of 1/100 in ICC/IF. Secondary used is an Alexa-Fluor^®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBP11 antibody (AB237528)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBP11 antibody (AB237528)

Paraffin-embedded human gastric cancer tissue stained for FKBP11 with ab237528 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBP11 antibody (AB237528)

Paraffin-embedded human pancreas tissue stained for FKBP11 with ab237528 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human FKBP11 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q9NYL4

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity greater than 95%

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FKBP11 also known as FK506 binding protein 11 or FK506-binding protein-like is an immunophilin with peptidyl-prolyl isomerase activity. It facilitates protein folding by accelerating protein folding through cis-trans isomerization of proline residues. The molecular weight of FKBP11 is approximately 19.8 kDa. This protein is primarily expressed in the endoplasmic reticulum and shows high expression levels in immune-related tissues such as the spleen and lymph nodes.

Biological function summary

FKBP11 plays a role in maintaining protein homeostasis in the cellular environment. It is involved in the folding and maturation of proteins particularly those that are endoplasmic reticulum-resident. FKBP11 is part of the tetratricopeptide repeat (TPR)-containing immunophilin family which often interacts with other proteins and complexes within the endoplasmic reticulum to assist in protein quality control and trafficking.

Pathways

FKBP11 participates in the unfolded protein response (UPR) which is an essential cellular pathway for managing stress related to misfolded proteins in the endoplasmic reticulum. It is also involved in the protein-folding pathway alongside other chaperones and peptidyl-prolyl isomerases including cyclophilins and other FK506-binding proteins. FKBP11 has functional interactions with key molecules such as HSP90 which is an important chaperone in protein maintenance.

FKBP11 has implications in conditions related to protein misfolding and endoplasmic reticulum stress including neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Aberrant expression or malfunction of FKBP11 can influence the progression of these disorders through its interaction with protein complexes involved in protein aggregation and neurotoxicity. FKBP11 indirectly connects to proteins like tau and α-synuclein which are central to the pathogenic processes of these neurological diseases.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

PPIases accelerate the folding of proteins during protein synthesis.

See full target information FKBP11

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular sciences 25: PubMed39063137

2024

Host Cells Upregulate Phosphate Transporter PIT1 to Inhibit Intracellular Growth.

Applications

Unspecified application

Species

Unspecified reactive species

Meifang Li,Nan Yang,Xiaoxiao Li,Nan Duan,Shanhua Qin,Mengyao Wang,Yuhong Zhou,Yongxin Jin,Weihui Wu,Shouguang Jin,Zhihui Cheng

OncoTargets and therapy 14:1007-1020 PubMed33603407

2021

Tandem Mass Tag-Based Proteomic Analysis of Potential Biomarkers for Hepatocellular Carcinoma Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wang,Qiang Li,Ge Huang,Bing-Yao Lin,Dongzi Lin,Yan Ma,Zhao Zhang,Tao Chen,Jie Zhou

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FKBP11 antibody

Immunocytochemistry/ Immunofluorescence - Anti-FKBP11 antibody (AB237528)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBP11 antibody (AB237528)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBP11 antibody (AB237528)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise