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AB264205

Anti-FKBP52 antibody

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Rabbit Polyclonal FKBP52 antibody. Suitable for WB and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human FKBP4 aa 400 to C-terminus.

대체 명칭 보기

FKBP52, FKBP4, Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4, 51 kDa FK506-binding protein, 52 kDa FK506-binding protein, 59 kDa immunophilin, FK506-binding protein 4, FKBP59, HSP-binding immunophilin, Immunophilin FKBP52, Rotamase, FKBP51, 52 kDa FKBP, FKBP-52, p59, FKBP-4, HBI

1 이미지
Western blot - Anti-FKBP52 antibody (AB264205)
  • WB

Supplier Data

Western blot - Anti-FKBP52 antibody (AB264205)

4-20% SDS-PAGE

All lanes:

Western blot - Anti-FKBP52 antibody (ab264205) at 0.04 µg/mL

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

HeLa whole cell lysate at 5 µg

Lane 4:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 5:

NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate at 50 µg

Predicted band size: 52 kDa

true

Exposure time: 10s

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human FKBP4 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q02790

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대체품

Primary Antibodies

AB129097

Anti-FKBP52 antibody [EPR6618]

KO Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-FKBP52 antibody [EPR6618] (AB129097)

  • 0
  • 0
Primary Antibodies

AB248052

Anti-FKBP52 antibody [EPR6619] - BSA and Azide free

KO Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBP52 antibody [EPR6619] - BSA and Azide free (AB248052)

  • 0
  • 0
Primary Antibodies

AB124906

Anti-FKBP52 antibody [EPR6619]

KO Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBP52 antibody [EPR6619] (AB124906)

  • 0
  • 0
Primary Antibodies

AB240535

Anti-FKBP52 antibody [EPR6618] - BSA and Azide free

KO Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-FKBP52 antibody [EPR6618] - BSA and Azide free (AB240535)

  • 0
  • 0
Primary Antibodies

AB230951

Anti-FKBP52 antibody [EPR21125]

RabMAb|Recombinant|Trial Size|Trial Size|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-FKBP52 antibody [EPR21125] (AB230951)

  • 0
  • 0
Primary Antibodies

AB237784

Anti-FKBP52 antibody [EPR21125] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-FKBP52 antibody [EPR21125] - BSA and Azide free (AB237784)

  • 0
  • 0

보완 제품

Assay Kits

AB309409

Human FKBP52 ELISA Kit

Sandwich ELISA - Human FKBP52 ELISA Kit (AB309409)

  • 0
  • 0
Primary Antibodies

AB79844

Anti-FKBP51 antibody [Hi51B]

KO Validated

Western blot - Anti-FKBP51 antibody [Hi51B] (AB79844)

  • 0
  • 0
Primary Antibodies

AB59459

Anti-Hsp90 antibody [D7a]

KO Validated

Western blot - Anti-Hsp90 antibody [D7a] (AB59459)

  • 5
  • 9
Primary Antibodies

AB190828

Anti-Hsp60 antibody [EPR18245-93] - Mitochondrial Marker

20ul selling size|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hsp60 antibody [EPR18245-93] - Mitochondrial Marker (AB190828)

  • 4
  • 4
Primary Antibodies

AB13495

Anti-Hsp90 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Hsp90 antibody (AB13495)

  • 4
  • 14
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The immunophilin protein FKBP52 also known as FK506-binding protein 4 (FKBP4) weighs approximately 52 kDa. This protein acts as a peptidyl-prolyl cis-trans isomerase which assists in protein folding and stability. FKBP52 is widely expressed in cells with high levels in tissues like the brain testis and kidneys indicating its role in various cellular processes. As part of its mechanical role FKBP52 interacts with heat shock proteins aiding in the regulation of protein homeostasis.
Biological function summary

FKBP52 functions as a co-chaperone in steroid receptor complexes. It partners with heat shock protein 90 (HSP90) to form a functional complex that modulates the activity of steroid hormone receptors. These receptors such as the androgen and glucocorticoid receptors rely on FKBP52 for proper regulation and transport within the cell. FKBP52 also plays a part in cellular signaling influencing processes like cell growth and differentiation through its interaction with these receptors.

Pathways

FKBP52 features prominently in steroid hormone signaling and stress response pathways. It is critical to the maturation and transport of steroid hormone receptors directly affecting their downstream gene regulation. The protein interacts closely with HSP90 and other immunophilins like FKBP51 which also plays roles in similar pathways but may have differing regulatory effects. This interaction demonstrates how FKBP52's function integrates into broader cellular signaling networks influencing pathways like the glucocorticoid receptor signaling pathway.

FKBP52 connects significantly to prostate cancer and Alzheimer's disease. In prostate cancer its modulation of androgen receptor activity is critical. Abnormal regulation of these receptors can contribute to cancer progression. Moreover in Alzheimer's disease FKBP52 influences the stability and function of tau protein which is linked to neurofibrillary tangle formation a hallmark of the disease. Its interaction with tau indicates a potential therapeutic target for intervention in Alzheimer's progression.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
See full target information FKBP4
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Product promise

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