AB72052

Anti-FMN2 antibody

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(8 제품이 사용된 논문 )

Rabbit Polyclonal FMN2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human FMN2.

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FMN2 antibody (AB72052)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FMN2 antibody (AB72052)

Immunohistochemical analysis of formalin fixed and paraffin embedded Human brain tissue section staining FMN2 using ab72052 at 1/300 dilution. HRP- labeled was used as the secondary antibody and hematoxylin was used as a nuclei counterstain.

Unknown

Western blot - Anti-FMN2 antibody (AB72052)

All lanes:

Western blot - Anti-FMN2 antibody (ab72052) at 0.25 µg/mL

Lane 1:

human brain lysate

Lane 2:

human brain lysate with immunising peptide

Predicted band size: 180 kDa

Observed band size: 150 kDa,67 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human FMN2. The exact immunogen used to generate this antibody is proprietary information.

Q9NZ56

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.25-0.5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/300 - 1/500", "IHCP-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed : 21730168, PubMed : 22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed : 21730168, PubMed : 22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed : 23375502). Also acts in the nucleus : together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed : 26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed : 23375502).

See full target information FMN2

대체 명칭 보기

Formin-2, FMN2

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제품이 사용된 논문 (8)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell chemical biology 29:1419-1433.e5 PubMed35738280

2022

A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection.

Applications

Unspecified application

Species

Unspecified reactive species

Kamalakannan Vijayan,Nadia Arang,Ling Wei,Robert Morrison,Rechel Geiger,K Rachael Parks,Adam J Lewis,Fred D Mast,Alyse N Douglass,Heather S Kain,John D Aitchison,Jarrod S Johnson,Alan Aderem,Alexis Kaushansky

Cells 10: PubMed34205257

2021

SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility of Breast Carcinoma Cells in Fibrillar ECM Microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Ved P Sharma,James Williams,Edison Leung,Joe Sanders,Robert Eddy,James Castracane,Maja H Oktay,David Entenberg,John S Condeelis

Clinical science (London, England : 1979) 133:2463-2479 PubMed31738400

2019

A novel circFMN2 promotes tumor proliferation in CRC by regulating the miR-1182/hTERT signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Yongchao Li,Changfeng Li,Ruisi Xu,Yun Wang,Dandan Li,Bin Zhang

Cell research 28:462-475 PubMed29463901

2018

Poly(ADP-ribose) mediates asymmetric division of mouse oocyte.

Applications

Unspecified application

Species

Unspecified reactive species

Bingteng Xie,Lu Zhang,Huiling Zhao,Qingyun Bai,Yong Fan,Xiaohui Zhu,Yang Yu,Rong Li,Xin Liang,Qing-Yuan Sun,Mo Li,Jie Qiao

Molecular cancer research : MCR 15:1579-1586 PubMed28811362

2017

Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb.

Applications

Unspecified application

Species

Unspecified reactive species

Zhe Yang,John Maciejowski,Titia de Lange

Cell 167:1571-1585.e18 PubMed27839864

2016

FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Colleen T Skau,Robert S Fischer,Pinar Gurel,Hawa Racine Thiam,Anthony Tubbs,Michelle A Baird,Michael W Davidson,Matthieu Piel,Gregory M Alushin,Andre Nussenzweig,Patricia S Steeg,Clare M Waterman

Nature communications 5:4887 PubMed25208553

2014

The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics.

Applications

Unspecified application

Species

Unspecified reactive species

Xing-Jiang Yu,Zhaohong Yi,Zheng Gao,Dandan Qin,Yanhua Zhai,Xue Chen,Yingchun Ou-Yang,Zhen-Bo Wang,Ping Zheng,Min-Sheng Zhu,Haibin Wang,Qing-Yuan Sun,Jurrien Dean,Lei Li

PloS one 8:e78428 PubMed24223803

2013

Metastasis suppressor microRNA-335 targets the formin family of actin nucleators.

Applications

Species

Human

Jennifer Lynch,Maria H Meehan,John Crean,John Copeland,Raymond L Stallings,Isabella M Bray

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FMN2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FMN2 antibody (AB72052)

Western blot - Anti-FMN2 antibody (AB72052)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (8)

Product promise