JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB228451

Anti-Folate Receptor 4 antibody [TH6]

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rat Monoclonal Folate Receptor 4 antibody. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Tissue preparation containing Izumo1r protein.

대체 명칭 보기

Folbp3, Folr4, Juno, Izumo1r, Sperm-egg fusion protein Juno, Folate receptor 4, Folate receptor delta, Folate-binding protein 3, IZUMO1 receptor protein JUNO, FR-delta

2 이미지
Flow Cytometry - Anti-Folate Receptor 4 antibody [TH6] (AB228451)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-Folate Receptor 4 antibody [TH6] (AB228451)

Flow cytometric analysis of mouse splenocytes labeling Folate Receptor 4 with ab228451 at 0.5 μg/106 cells.

Cells were first stained with an anti-mCD3 APC conjugated; mCD3 APC positive cells were gated and further analyzed for mouse Folate Receptor 4 using ab228451. Goat anti-Rat PE was used as the secondary antibody.

Flow Cytometry - Anti-Folate Receptor 4 antibody [TH6] (AB228451)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-Folate Receptor 4 antibody [TH6] (AB228451)

Flow cytometric analysis of mouse thymocytes labeling Folate Receptor 4 with ab228451 at 0.5 μg/106 cells.

Cells were first stained with an anti-mCD3 APC conjugated; mCD3 APC positive cells were gated and further analyzed for mouse Folate Receptor 4 using ab228451. Goat anti-Rat PE was used as the secondary antibody.

주요 정보

Host species

Rat

Clonality

Monoclonal

Clone number

TH6

Isotype

IgG2b

Light chain 타입

kappa

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Tissue preparation containing Izumo1r protein. The exact immunogen used to generate this antibody is proprietary information.

Q9EQF4

style
left-column

대체품

Primary Antibodies

AB233142

Anti-Folate Receptor 4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Folate Receptor 4 antibody (AB233142)

  • 0
  • 0

보완 제품

Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
Primary Antibodies

AB211623

Anti-IZUMO1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-IZUMO1 antibody (AB211623)

  • 0
  • 0
Primary Antibodies

AB137869

Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (AB137869)

  • 5
  • 9
Primary Antibodies

AB177487

Anti-NeuN antibody [EPR12763] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-NeuN antibody [EPR12763] - Neuronal Marker (AB177487)

  • 5
  • 75
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.5-1 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purified from TCS.
보관 버퍼
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Folate Receptor 4 (FR4) also known as delta folate receptor is involved in the high-affinity binding and transport of folate and folate analogs across the cell membrane. Folate is an essential vitamin B9 derivative which cells use for important functions like DNA synthesis and repair. FR4 has a mass of approximately 30 kilodaltons. Researchers have found this receptor mainly on the surface of activated T cells which play an important role in the immune system.
Biological function summary

FR4 aids in the uptake of folate compounds necessary for cellular proliferation and survival. It is not generally part of a larger protein complex but it competes with other folate receptors like folate receptor alpha for binding to available folate molecules. The receptor’s function directly supports T cell activity and survival impacting immune responses.

Pathways

The folate receptor FR4 contributes to immune response pathways by ensuring an adequate supply of folate for T cells. It is a part of the broader folate metabolism pathway which also involves proteins such as dihydrofolate reductase (DHFR) that further process folate for nucleic acid synthesis. This participation in folate metabolism supports not only primary cellular functions but also the specialized activity of immune cells.

FR4 is notably associated with autoimmune diseases such as rheumatoid arthritis where abnormal expression levels have been observed in T cells. Also FR4 connects indirectly to cancer as altered folate metabolism can contribute to oncogenesis. Although it functions separately from proteins like thymidylate synthase which is directly involved in cancer proliferation both are part of the overall metabolic pathways impacting disease progression.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization (PubMed : 24739963, PubMed : 26859261, PubMed : 27309808, PubMed : 27416963). The IZUMO1 : IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed : 24739963, PubMed : 26859261, PubMed : 27309808). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed : 24739963, PubMed : 26859261, PubMed : 27309808). Does not bind folate (PubMed : 24739963).
See full target information Izumo1r
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of cell communication and signaling 19:e70016 PubMed40401147

2025

ELAVL1 promotes ferroptosis via the TRIM21/HOXD8 axis to inhibit osteogenic differentiation in congenital pseudoarticular tibia-derived mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Weihua Ye,Zheng Liu,Yaoxi Liu,Han Xiao,Qian Tan,An Yan,Guanghui Zhu
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com