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AB237030

Anti-FOXE3 antibody

1

(1 리뷰)

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(1 출판물)

Rabbit Polyclonal FOXE3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FOXE3 aa 1-100.

대체 명칭 보기

FKHL12, FREAC8, FOXE3, Forkhead box protein E3, Forkhead-related protein FKHL12, Forkhead-related transcription factor 8, FREAC-8

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-FOXE3 antibody (AB237030)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FOXE3 antibody (AB237030)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for FOXE3 using ab237030 at 1/166 dilution in ICC/IF.

The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal goat serum. The cells were then incubated with the primary antibody overnight at 4°C. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L). Counterstained with DAPI.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human FOXE3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q13461

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보완 제품

Primary Antibodies

AB32537

Anti-ERK1 antibody [Y72]

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Flow Cytometry (Intracellular) - Anti-ERK1 antibody [Y72] (AB32537)

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  • 4
Primary Antibodies

AB195045

Anti-PAX6 antibody [EPR15858]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAX6 antibody [EPR15858] (AB195045)

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  • 9
Primary Antibodies

AB184787

Anti-Caspase-3 antibody [EPR18297]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-3 antibody [EPR18297] (AB184787)

  • 3
  • 3
Primary Antibodies

AB222885

Anti-Cx50 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cx50 antibody (AB222885)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FOXE3 also known as forkhead box E3 is a transcription factor weighing approximately 33 kDa. It exhibits expression predominantly in the eye lens particularly during development. As a member of the forkhead family of transcription factors FOXE3 plays key roles in the regulation of gene expression. Mammalian species show high conservation of FOXE3 gene sequences reflecting its importance across different organisms.
Biological function summary

Interaction with other proteins is important for FOXE3's function particularly in the differentiation of lens fiber cells and lens development. This transcription factor ensures proper lens morphogenesis maintaining transparency and preventing cataract formation. Though its primary activity lies in the eye FOXE3 can influence other tissues by regulating gene expression pertinent to epithelial cell development. Current data suggests FOXE3 does not form large multi-protein complexes but interacts with specific gene promoters to exert its function.

Pathways

FOXE3 activity integrates into the lens development and morphogenesis pathways. It regulates genes such as CRYAA and MIP important for lens transparency and cell differentiation. FOXE3 works closely with PAX6 and SOX2 proteins that are also pivotal in the eye development pathway. These interactions highlight its integral role in eye development processes and maintenance of tissue homeostasis within the ocular microenvironment.

FOXE3 mutations or dysregulation associate with congenital cataracts and anterior segment dysgenesis. Anomalies in FOXE3 expression can cause severe developmental disorders in the eye leading to visual impairment or blindness. The PAX6 gene can also contribute to similar disorders establishing a genetic linkage between the two in their disease manifestations. Researchers continue to explore FOXE3's involvement in these pathologies to develop potential therapeutic strategies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed : 22527307, PubMed : 25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed : 27218149).
See full target information FOXE3
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 30:e13562 PubMed38279604

2024

Cosentyx alleviates psoriasis-induced podocyte injury by inhibiting the tlr/nf-κb signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wang Aixue,Wei Feng,Zhang Huanhuan,M Xixing,L Yanling
제품이 사용된 논문 모두 보기
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Product promise

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