AB66430
Rabbit Polyclonal GABA A Receptor beta 3/GABRB3 antibody. Suitable for ELISA, WB, IHC-P, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GABRB3.
대체품
![Flow Cytometry - Anti-GABA A Receptor beta 3/GABRB3 antibody [N87/25] (AB98968)](https://content.abcam.com/products/images/gaba-a-receptor-beta-3-gabrb3-antibody-n87-25-ab98968--flow-cytometry-img50181.jpg)
보완 제품
Primary Antibodies
AB52922
20ul selling size|RabMAb|Recombinant|KO Validated
![Immunoprecipitation - Anti-HLA A antibody [EP1395Y] (AB52922)](https://content.abcam.com/products/images/hla-a-antibody-ep1395y-ab52922--immunoprecipitation-img273.jpg)
- 4
- 15
Primary Antibodies
AB138492
Anti-Collagen I antibody [EPR7785]
20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials
![Immunohistochemistry (Frozen sections) - Anti-Collagen I antibody [EPR7785] (AB138492)](https://content.abcam.com/products/images/collagen-i-antibody-epr7785-ab138492--immunohistochemistry-frozen-sections-img179180.jpg)
- 4
- 37
Reactivity 정보
{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Mouse": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Rat": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
제품 세부 정보
We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 23rd June 2017. The following lots are still unpurified and still in stock as of 23rd June 2017 - GR325257-1, GR325257-2, GR325257-3, GR325257-4, GR325257-5, GR325257-6, GR1530-9, GR1530-10. Lot numbers other than GR325257-1, GR325257-2, GR325257-3, GR325257-4, GR325257-5, GR325257-6, GR1530-9, GR1530-10 will be purified. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.
특성 및 보관 정보
제형
Lyophilized
Reconstitution
Reconstitute with 100µl Water.
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
제품 프로토콜
For this product, it's our understanding that no specific protocols are required. You can visit:
- Visit the General protocols
- Visit the Troubleshooting
타겟 정보
Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed : 14993607, PubMed : 18514161, PubMed : 22243422, PubMed : 22303015, PubMed : 24909990, PubMed : 26950270, PubMed : 30602789). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed : 24909990, PubMed : 30140029, PubMed : 30602789). GABAARs containing beta-3/GABRB3 subunit are found at both synaptic and extrasynaptic sites (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed : 14993607, PubMed : 22303015, PubMed : 26950270, PubMed : 30602789). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed : 22303015, PubMed : 26950270). GABAARs containing alpha-1 and beta-3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed : 25489750). Extrasynaptic beta-3 receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs containing alpha-1, beta-3 and epsilon subunits may also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed : 18281286, PubMed : 24909990, PubMed : 35355020). Plays an important role in somatosensation and in the production of antinociception (By similarity).
대체 명칭 보기
Gamma-aminobutyric acid receptor subunit beta-3, GABA(A) receptor subunit beta-3, GABAAR subunit beta-3, GABRB3
제품이 사용된 논문 (1)
Recent publications for all applications. Explore the 전체 목록 and refine your search
PloS one 7:e36319 PubMed22563490
2012
Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity.
Applications
ELISA, Flow Cyt
Species
Human, Human
Laurence Desrues,Thomas Lefebvre,Céline Lecointre,Marie-Thérèse Schouft,Jérôme Leprince,Vincent Compère,Fabrice Morin,François Proust,Pierrick Gandolfo,Marie-Christine Tonon,Hélène Castel
Product promise
저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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