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AB187516

Anti-GALNS/Chondroitinase antibody

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Rabbit Polyclonal GALNS/Chondroitinase antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human N-acetylgalactosamine-6-sulfatase aa 350 to C-terminus.

대체 명칭 보기

N-acetylgalactosamine-6-sulfatase, Chondroitinsulfatase, Galactose-6-sulfate sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, Chondroitinase, GalN6S, GalNAc6S sulfatase, GALNS

1 이미지
Western blot - Anti-GALNS/Chondroitinase antibody (AB187516)
  • WB

Supplier Data

Western blot - Anti-GALNS/Chondroitinase antibody (AB187516)

All lanes:

Western blot - Anti-GALNS/Chondroitinase antibody (ab187516) at 1/500 dilution

Lane 1:

MCF7 cell extract

Lane 2:

HT29 cell extract

Lane 3:

293T cell extract

Lane 4:

Mouse kidney extract

Lane 5:

Mouse brain extract

Lane 6:

Mouse intestine extract

Predicted band size: 58 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human N-acetylgalactosamine-6-sulfatase aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P34059

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대체품

Primary Antibodies

AB231647

Anti-GALNS/Chondroitinase antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALNS/Chondroitinase antibody (AB231647)

  • 0
  • 0

보완 제품

Primary Antibodies

AB85727

Anti-ARSB antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARSB antibody (AB85727)

  • 0
  • 0
Primary Antibodies

AB254352

Anti-GLP-1R antibody [EPR23507-57]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLP-1R antibody [EPR23507-57] (AB254352)

  • 1
  • 1
Proteins & Peptides

AB151647

Recombinant Human FGE protein

  • 0
  • 0
Reagents, Controls & Accessories

AB171522

TMB ELISA Substrate (Highest Sensitivity)

ELISA - TMB ELISA Substrate (Highest Sensitivity) (AB171522)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Chondroitinase also known as N-acetylgalactosamine-6-sulfatase (GALNS) is an enzyme involved in the degradation of glycosaminoglycans such as chondroitin sulfate and keratan sulfate. It is a lysosomal hydrolase enzyme that plays an important role in remodeling the extracellular matrix by cleaving sulfate groups from these molecules. The molecular mass of GALNS is approximately 60 kDa. GALNS expression primarily occurs in tissues like cartilage bones and connective tissues reflecting its function in skeletal development and maintenance.
Biological function summary

N-acetylgalactosamine-6-sulfatase acts as a critical player in catabolism breaking down complex polysaccharides in lysosomes. By degrading glycosaminoglycans it prevents accumulation of excessive polysaccharides in cells which might lead to cellular dysfunction. GALNS operates as a single molecule not forming any known complexes yet its activity is integral to maintaining cellular homeostasis and preventing pathological buildup of substrates within cells.

Pathways

GALNS functions in the glycosaminoglycan metabolism pathway essential for recycling cellular materials from the extracellular matrix. Another related pathway is the lysosomal degradation pathway where it relates to other enzymes like iduronate-2-sulfatase that also participate in the breakdown of complex molecules. These pathways collectively help in maintaining normal cellular function by facilitating the turnover of matrix components.

N-acetylgalactosamine-6-sulfatase relates to Morquio A syndrome a lysosomal storage disorder caused by deficiencies in GALNS activity. This leads to abnormal accumulation of keratan sulfate and chondroitin sulfate resulting in skeletal abnormalities and growth issues. GALNS has also connections to mucopolysaccharidosis IV where defects in this enzyme similarly cause buildup of glycosaminoglycans. Proteins like N-sulfoglucosamine sulfohydrolase show association with GALNS through shared pathways in these disorders highlighting the interconnected nature of enzyme functions in lysosomal storage diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information N-acetylgalactosamine-6-sulfatase
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports. Medicine 5:101593 PubMed38843842

2024

Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice.

Applications

Unspecified application

Species

Unspecified reactive species

Diego Acuña-Catalán,Samah Shah,Cameron Wehrfritz,Mitsunori Nomura,Alejandro Acevedo,Cristina Olmos,Gabriel Quiroz,Hernán Huerta,Joanna Bons,Estibaliz Ampuero,Ursula Wyneken,Magdalena Sanhueza,Felipe Arancibia,Darwin Contreras,Julio César Cárdenas,Bernardo Morales,Birgit Schilling,John C Newman,Christian González-Billault
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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