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AB231647

Anti-GALNS/Chondroitinase antibody

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Rabbit Polyclonal GALNS/Chondroitinase antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Recombinant full length protein - Rat, Pig samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Rat N-acetylgalactosamine-6-sulfatase aa 150-400.

대체 명칭 보기

N-acetylgalactosamine-6-sulfatase, Chondroitinsulfatase, Galactose-6-sulfate sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, Chondroitinase, GalNAc6S sulfatase, Galns

4 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALNS/Chondroitinase antibody (AB231647)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALNS/Chondroitinase antibody (AB231647)

Paraffin-embedded rat kidney tissue stained for GALNS/Chondroitinase using ab231647 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALNS/Chondroitinase antibody (AB231647)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALNS/Chondroitinase antibody (AB231647)

Paraffin-embedded rat kidney tissue stained for GALNS/Chondroitinase using ab231647 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-GALNS/Chondroitinase antibody (AB231647)
  • WB

Supplier Data

Western blot - Anti-GALNS/Chondroitinase antibody (AB231647)

All lanes:

Western blot - Anti-GALNS/Chondroitinase antibody (ab231647) at 3 µg/mL

Lane 1:

Mouse liver lysate

Lane 2:

Pig liver lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 56 kDa,58 kDa

false

Western blot - Anti-GALNS/Chondroitinase antibody (AB231647)
  • WB

Supplier Data

Western blot - Anti-GALNS/Chondroitinase antibody (AB231647)

All lanes:

Western blot - Anti-GALNS/Chondroitinase antibody (ab231647) at 3 µg/mL

All lanes:

Recombinant rat GALNS/Chondroitinase protein

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 58 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Rat N-acetylgalactosamine-6-sulfatase aa 150-400. The exact immunogen used to generate this antibody is proprietary information.

Q32KJ6

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대체품

Primary Antibodies

AB187516

Anti-GALNS/Chondroitinase antibody

Western blot - Anti-GALNS/Chondroitinase antibody (AB187516)

  • 0
  • 0

보완 제품

Primary Antibodies

AB316860

Anti-EBV Nuclear Antigen/EBNA1 antibody [EPR28706-78]

BOND RX™ Validated|20ul selling size|Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EBV Nuclear Antigen/EBNA1 antibody [EPR28706-78] (AB316860)

  • 0
  • 0
Primary Antibodies

AB85727

Anti-ARSB antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARSB antibody (AB85727)

  • 0
  • 0
Primary Antibodies

AB16126

Anti-EBNA 3A antibody

Western blot - Anti-EBNA 3A antibody (AB16126)

  • 4
  • 1
Reagents, Controls & Accessories

AB210900

Stop Solution 1X

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant full length protein - Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab231647 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Chondroitinase also known as N-acetylgalactosamine-6-sulfatase (GALNS) is an enzyme involved in the degradation of glycosaminoglycans such as chondroitin sulfate and keratan sulfate. It is a lysosomal hydrolase enzyme that plays an important role in remodeling the extracellular matrix by cleaving sulfate groups from these molecules. The molecular mass of GALNS is approximately 60 kDa. GALNS expression primarily occurs in tissues like cartilage bones and connective tissues reflecting its function in skeletal development and maintenance.
Biological function summary

N-acetylgalactosamine-6-sulfatase acts as a critical player in catabolism breaking down complex polysaccharides in lysosomes. By degrading glycosaminoglycans it prevents accumulation of excessive polysaccharides in cells which might lead to cellular dysfunction. GALNS operates as a single molecule not forming any known complexes yet its activity is integral to maintaining cellular homeostasis and preventing pathological buildup of substrates within cells.

Pathways

GALNS functions in the glycosaminoglycan metabolism pathway essential for recycling cellular materials from the extracellular matrix. Another related pathway is the lysosomal degradation pathway where it relates to other enzymes like iduronate-2-sulfatase that also participate in the breakdown of complex molecules. These pathways collectively help in maintaining normal cellular function by facilitating the turnover of matrix components.

N-acetylgalactosamine-6-sulfatase relates to Morquio A syndrome a lysosomal storage disorder caused by deficiencies in GALNS activity. This leads to abnormal accumulation of keratan sulfate and chondroitin sulfate resulting in skeletal abnormalities and growth issues. GALNS has also connections to mucopolysaccharidosis IV where defects in this enzyme similarly cause buildup of glycosaminoglycans. Proteins like N-sulfoglucosamine sulfohydrolase show association with GALNS through shared pathways in these disorders highlighting the interconnected nature of enzyme functions in lysosomal storage diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information N-acetylgalactosamine-6-sulfatase
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

CNS neuroscience & therapeutics 30:e70098 PubMed39491498

2024

Fasudil Alleviates Postoperative Neurocognitive Disorders in Mice by Downregulating the Surface Expression of α5GABAAR in Hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Jinpeng Dong,Zhun Wang,Lixuan Li,Mengxue Zhang,Sixuan Wang,Yuan Luo,Ying Dong,Xiaokun Wang,Yongan Wang,Kaiyuan Wang,Yiqing Yin
제품이 사용된 논문 모두 보기
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Product promise

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