JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB127198

Anti-GAS41 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal GAS41 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human YEATS4 aa 1-200.

대체 명칭 보기

GAS41, YEATS4, YEATS domain-containing protein 4, Glioma-amplified sequence 41, NuMA-binding protein 1, Gas41, NuBI-1, NuBI1

1 이미지
Western blot - Anti-GAS41 antibody (AB127198)
  • WB

Unknown

Western blot - Anti-GAS41 antibody (AB127198)

12% SDS-PAGE

All lanes:

Western blot - Anti-GAS41 antibody (ab127198) at 1/1000 dilution

All lanes:

A549 whole cell lysate at 30 µg

Predicted band size: 26 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human YEATS4 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

O95619

style
left-column

대체품

Primary Antibodies

AB205018

Anti-GAS41 antibody

Immunoprecipitation - Anti-GAS41 antibody (AB205018)

  • 5
  • 1

보완 제품

Primary Antibodies

AB4729

Anti-Histone H3 (acetyl K27) antibody - ChIP Grade

BOND RX™ Validated

ChIP - Anti-Histone H3 (acetyl K27) antibody - ChIP Grade (AB4729)

  • 5
  • 85
Primary Antibodies

AB177427

Anti-Histone H2B (acetyl K16) antibody [EPR17598] - ChIP Grade

RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Histone H2B (acetyl K16) antibody [EPR17598] - ChIP Grade (AB177427)

  • 5
  • 2
Primary Antibodies

AB17969

Anti-BRD8/p120 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD8/p120 antibody (AB17969)

  • 0
  • 0
Primary Antibodies

AB133273

Anti-Androgen Receptor antibody [EPR1535(2)]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Androgen Receptor antibody [EPR1535(2)] (AB133273)

  • 5
  • 12
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Sheep": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein GAS41 also known as Glioma-Amplified Sequence 41 weighs approximately 26 kDa. It is ubiquitously expressed in various cell types including brain and neuronal tissues. GAS41 performs as a component of the chromatin remodeling complex. This protein participates in DNA binding and potentially regulates transcription processes influencing gene expression patterns.
Biological function summary

GAS41 impacts cellular proliferation and organization. It is often part of the Tip60/NuA4 histone acetyltransferase complex which is involved in chromatin modification. Through its role in this complex GAS41 influences transcriptional regulation by modifying chromatin architecture. This process ultimately affects how genes are turned on or off in cells which is key for maintaining cellular function and identity.

Pathways

GAS41 plays a significant role in the regulation of gene expression pathways and cell cycle control. It interacts with proteins in the SWI/SNF-related chromatin remodeler pathways and modulates how genes involved in cell cycle progression are expressed. GAS41 shows interaction with proteins like p400 which also contributes to these pathways indicating its importance in cellular growth and division.

GAS41 is linked to glioma progression and certain neurodegenerative disorders. Changes in the expression of GAS41 have been observed in gliomas connecting it with the uncontrolled cell growth characteristic of these tumors. Through its association with other proteins like ATRX GAS41 is implicated in chromatin remodeling disturbances seen in neurodegenerative diseases influencing gene expression patterns and contributing to disease pathogenesis.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed : 12963728, PubMed : 14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed : 29437725, PubMed : 29900004, PubMed : 30071723). Also able to recognize and bind crotonylated histone H3 (PubMed : 30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed : 29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions : recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed : 29437725). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity).
See full target information YEATS4
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular medicine reports 32: PubMed40709397

2025

Pan‑cancer analysis of the carcinogenic role of WSB2 in human tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Yingzi Deng,Yifei Li,Ruobing Li,Xiaohui Guo,Yan Liu,Shuqing Wang,Juan Zhang,Mi Li,Lina Zhao,Haifeng Cai,Yunfeng Zhang,Fen Hu
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com