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AB230990

Anti-Gastrokine 1 antibody

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Rabbit Polyclonal Gastrokine 1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 1 publication.

대체 명칭 보기

Amp18, Ca11, Gkn1, Gastrokine-1, 18 kDa antrum mucosa protein, Protein CA11 homolog, AMP-18

4 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastrokine 1 antibody (AB230990)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastrokine 1 antibody (AB230990)

Formalin-fixed, paraffin-embedded rat stomach tissue stained for Gastrokine 1 with ab230990 at 20 μg/ml in immunohistochemical analysis.

Western blot - Anti-Gastrokine 1 antibody (AB230990)
  • WB

Supplier Data

Western blot - Anti-Gastrokine 1 antibody (AB230990)

All lanes:

Western blot - Anti-Gastrokine 1 antibody (ab230990) at 2 µg/mL

All lanes:

Recombinant rat Gastrokine 1 protein

Predicted band size: 22 kDa,85 kDa

false

Western blot - Anti-Gastrokine 1 antibody (AB230990)
  • WB

Supplier Data

Western blot - Anti-Gastrokine 1 antibody (AB230990)

All lanes:

Western blot - Anti-Gastrokine 1 antibody (ab230990) at 2 µg/mL

All lanes:

Mouse stomach lysate

Predicted band size: 22 kDa

false

Western blot - Anti-Gastrokine 1 antibody (AB230990)
  • WB

Supplier Data

Western blot - Anti-Gastrokine 1 antibody (AB230990)

All lanes:

Western blot - Anti-Gastrokine 1 antibody (ab230990) at 2 µg/mL

All lanes:

Rat stomach lysate

Predicted band size: 10 kDa,11 kDa,15 kDa,19 kDa,22 kDa,26 kDa,31 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

WB, IHC-P

applications

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대체품

Primary Antibodies

AB203094

Anti-Gastrokine 1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastrokine 1 antibody (AB203094)

  • 0
  • 0
Primary Antibodies

AB231952

Anti-Gastrokine 1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastrokine 1 antibody (AB231952)

  • 0
  • 0

보완 제품

Primary Antibodies

AB188866

Anti-GKN2 antibody [EPR15377(B)] - C-terminal

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GKN2 antibody [EPR15377(B)] - C-terminal (AB188866)

  • 0
  • 0
Primary Antibodies

AB223846

Anti-Gastric Mucin/MUC-6 antibody [EPR20623]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastric Mucin/MUC-6 antibody [EPR20623] (AB223846)

  • 4
  • 2
Proteins & Peptides

AB131669

Recombinant Human Gastrokine 1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Gastrokine 1 protein (His tag N-Terminus) (AB131669)

  • 0
  • 0
Primary Antibodies

AB192890

Anti-LC3B antibody [EPR18709] - Autophagosome Marker

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Western blot - Anti-LC3B antibody [EPR18709] - Autophagosome Marker (AB192890)

  • 5
  • 19
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab230990 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
보관 버퍼
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Gastrokine 1 also known as GKN1 is a protein with a molecular weight of approximately 18 kDa. It is expressed mainly in the gastric epithelium. This protein plays a mechanical role in maintaining gastric mucosal integrity. It has been associated with epithelial cell differentiation and proliferation a process important for stomach lining health. Gastrokine 1 interacts with other cellular components to stabilize and repair the gastric mucosa following injury or stress.
Biological function summary

This protein supports gastric mucosal defense mechanisms. It participates in maintaining the epithelial barrier against harmful digestive enzymes and pathogens. Gastrokine 1 is not part of a larger protein complex but operates independently to influence mucosal protection. Its ability to modulate cell turnover and repair processes highlights its importance in sustaining gastric homeostasis.

Pathways

Gastrokine 1 functions within the gastric mucosal protective pathway. It often relates to the signaling pathways involving epidermal growth factor receptor (EGFR) and inflammation mediation. The absence or reduction of GKN1 can disrupt these pathways impacting other proteins such as MUC5AC which also contribute to the protective mucosal barrier. The interaction between these proteins ensures a coordinated response in maintaining the stomach lining integrity.

Alterations in Gastrokine 1 expression have associations with gastric cancer and gastritis. Reduced levels of this protein often correspond with increased gastric epithelial damage and carcinogenesis risks. GKN1's association with diseases like gastric cancer makes it a potential biomarker. Additionally its interaction with Helicobacter pylori a bacterium linked to chronic gastritis and cancer demonstrates the protein's critical role in disease prevention.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
See full target information Gkn1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of virology 95: PubMed33361420

2021

Fowl Adenovirus Serotype 4 Induces Hepatic Steatosis via Activation of Liver X Receptor-α.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Yuan,Lei Hou,Li Wei,Rong Quan,Jing Wang,Hao Liu,Jue Liu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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