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AB236387

Anti-GCH1 antibody [OTI5A1]

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(6 제품이 사용된 논문 )

Mouse Monoclonal GCH1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GCH1.

대체 명칭 보기

DYT5, GCH, GCH1, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GCH1 antibody [OTI5A1] (AB236387)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GCH1 antibody [OTI5A1] (AB236387)

Paraffin-embedded human skin tissue stained for GCH1 using ab236387 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GCH1 antibody [OTI5A1] (AB236387)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GCH1 antibody [OTI5A1] (AB236387)

Paraffin-embedded human placenta tissue stained for GCH1 using ab236387 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GCH1 antibody [OTI5A1] (AB236387)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GCH1 antibody [OTI5A1] (AB236387)

Paraffin-embedded human spleen carcinoma tissue stained for GCH1 using ab236387 at 1/500 dilution in immunohistochemical analysis.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI5A1

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human GCH1.

P30793

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from cell culture supernatant.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

타겟 정보

Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.
See full target information GCH1

제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Redox biology 73:103207 PubMed38805974

2024

Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Shuohui Dong,Mingguang Zhang,Zhiqiang Cheng,Xiang Zhang,Weili Liang,Songhan Li,Linchuan Li,Qian Xu,Siyi Song,Zitian Liu,Guangwei Yang,Xiang Zhao,Ze Tao,Shuo Liang,Kexin Wang,Guangyong Zhang,Sanyuan Hu

Methods in molecular biology (Clifton, N.J.) 2712:211-222 PubMed37578709

2023

Detection of Ferroptosis by Immunohistochemistry and Immunofluorescence.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Zhong,Ruochan Chen

Journal of oncology 2023:1453739 PubMed36793373

2023

Suppression of GCH1 Sensitizes Ovarian Cancer and Breast Cancer to PARP Inhibitor.

Applications

Unspecified application

Species

Unspecified reactive species

Siyuan Wang,Yu Xia,Pu Huang,Cheng Xu,Yiyu Qian,Tian Fang,Qinglei Gao

Frontiers in cell and developmental biology 10:810327 PubMed35223839

2022

Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Hu,Wanhui Wei,Daiqian Wu,Fengxing Huang,Mengting Li,Wenjie Li,Jingwen Yin,Yanan Peng,Yuanyuan Lu,Qiu Zhao,Lan Liu

Molecular medicine reports 18:3350-3358 PubMed30085331

2018

Exendin‑4 reverses endothelial dysfunction in mice fed a high‑cholesterol diet by a GTP cyclohydrolase‑1/tetrahydrobiopterin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiqi Tang,Lijuan Liu,Yujie Guo,Guoxiong Deng,Meixiang Chen,Jinru Wei

International journal of cancer 132:591-604 PubMed22753274

2012

Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Geethanjali Pickert,Hee-Young Lim,Andreas Weigert,Annett Häussler,Thekla Myrczek,Maximilian Waldner,Sandra Labocha,Nerea Ferreirós,Gerd Geisslinger,Jörn Lötsch,Christoph Becker,Bernhard Brüne,Irmgard Tegeder
제품이 사용된 논문 모두 보기

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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