AB8027

Anti-GDNF Receptor alpha 2/GFRA2 antibody

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(5 제품이 사용된 논문 )

Rabbit Polyclonal GDNF Receptor alpha 2/GFRA2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications.

2 이미지

Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 2/GFRA2 antibody (AB8027)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 2/GFRA2 antibody (AB8027)

ab8027 at 5μg/ml staining GDNF Receptor alpha2/GFRA2 in Hela cells by ICC/IF.

Unknown

Western blot - Anti-GDNF Receptor alpha 2/GFRA2 antibody (AB8027)

All lanes:

Western blot - Anti-GDNF Receptor alpha 2/GFRA2 antibody (ab8027) at 1/1000 dilution

All lanes:

HeLa total cell lysate

Predicted band size: 52 kDa

Observed band size: 52 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "5 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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제품 세부 정보

Members of the glial cell line-derived neurotrophic factor(GDNF) family, including GDNF and neurturin (NTN),play key roles in the control of vertebrate neuron survivaland differentiation. Physiological responses to NTN requirethe presence of a novel glycosylphosphadidylinositollinked protein NTNRa, which is a cell surface receptor forNTN. The cDNAs encoding NTNRa from human, rat,chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2)or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal andto mediate NTN function.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Ion exchange chromatography

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons (PubMed : 10829012, PubMed : 29414779, PubMed : 31535977, PubMed : 9182803). NRTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed : 31535977). Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (PubMed : 9182803).. Isoform 2. Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.

See full target information GFRA2

대체 명칭 보기

GDNFRB, RETL2, TRNR2, GFRA2, GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, GDNFR-beta, NRTNR-alpha, NTNR-alpha

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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

PloS one 14:e0216527 PubMed31107888

2019

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin.

Applications

Unspecified application

Species

Unspecified reactive species

Frank L Rice,George Houk,James P Wymer,Sara J C Gosline,Justin Guinney,Jianqiang Wu,Nancy Ratner,Michael P Jankowski,Salvo La Rosa,Marilyn Dockum,James R Storey,Steven L Carroll,Phillip J Albrecht,Vincent M Riccardi

Biochemical and biophysical research communication 510:339-344 PubMed30722993

2019

GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN.

Applications

Unspecified application

Species

Unspecified reactive species

Zuoqing Li,Juntao Xie,Yingchun Fei,Pengfei Gao,Qigen Xie,Wenzong Gao,Zhe Xu

Clinical cancer research : an official journal of the American Association for Cancer Research 20:140-150 PubMed24150232

2013

Transient activation of hedgehog pathway rescued irradiation-induced hyposalivation by preserving salivary stem/progenitor cells and parasympathetic innervation.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Hai,Lizheng Qin,Zhenhua Yang,Qingguo Zhao,Lei Shangguan,Xinyu Ti,Yanqiu Zhao,Sangroh Kim,Dharanipathy Rangaraj,Fei Liu

Carcinogenesis 35:103-13 PubMed24067900

2013

The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer.

Applications

IHC

Species

Human

Kun Wang,Ihsan Ekin Demir,Jan G D'Haese,Elke Tieftrunk,Kristina Kujundzic,Stephan Schorn,Baocai Xing,Timo Kehl,Helmut Friess,Güralp O Ceyhan

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 23:425-38 PubMed16002253

2005

Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human hippocampus and fascia dentata.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Pina Serra,Marina Quartu,Francesca Mascia,Annalisa Manca,Marianna Boi,M Giuseppina Pisu,Maria Letizia Lai,Marina Del Fiacco

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GDNF Receptor alpha 2/GFRA2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 2/GFRA2 antibody (AB8027)

Western blot - Anti-GDNF Receptor alpha 2/GFRA2 antibody (AB8027)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (5)

Product promise