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AB96168

Anti-GIRK1 antibody

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Rabbit Polyclonal GIRK1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KCNJ3 aa 200-550.
1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GIRK1 antibody (AB96168)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GIRK1 antibody (AB96168)

Immunohistochemical analysis of paraffin-embedded DU145 xenograft, using ab96168 at 1 : 100 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human KCNJ3 aa 200-550. The exact immunogen used to generate this antibody is proprietary information.

P48549

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보완 제품

Primary Antibodies

AB16702

Anti-CD23 antibody [SP23]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry - Anti-CD23 antibody [SP23] (AB16702)

  • 0
  • 0
Primary Antibodies

AB219074

Anti-KCNJ5 antibody [8D2]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KCNJ5 antibody [8D2] (AB219074)

  • 0
  • 0
Primary Antibodies

AB65096

Anti-GIRK2 antibody

Western blot - Anti-GIRK2 antibody (AB65096)

  • 4
  • 1
Primary Antibodies

AB308260

Anti-Arx antibody [EPR27481-32]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Multiplex immunohistochemistry - Anti-Arx antibody [EPR27481-32] (AB308260)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GIRK1 also known as Kir3.1 or KCNJ3 is a potassium channel protein that contributes to the regulation of potassium ion flow across cell membranes. It has a molecular mass of approximately 56 kDa. GIRK1 forms an important part of the inwardly rectifying potassium channels (Kir) and is expressed in various tissues most notably in the brain and heart. These channels allow the inward flow of K+ ions which are essential for many cellular processes.
Biological function summary

GIRK1 plays an important role in maintaining the resting membrane potential and neuronal excitability. It often forms a functional complex with other GIRK subunits such as GIRK2 and GIRK4 to mediate its effects. By responding to different neurotransmitters and coupling with G-protein-coupled receptors GIRK1 helps in neurotransmission regulation and contributes to the heart rate control.

Pathways

GIRK1 is involved in the G-protein coupled receptor (GPCR) signaling pathway and the atrial muscarinic acetylcholine receptor signaling pathway. This protein works closely with G-protein beta-gamma subunits which activate these pathways leading to increased potassium permeability. This regulation influences vital physiological processes like slowing the heart rate and modulating neural signals.

GIRK1 has connections to cardiac arrhythmias and epilepsy. Dysfunction in GIRK1-mediated channels can result in abnormal heart rhythms often linked with other proteins like GIRK4. In the nervous system aberrant GIRK1 function contributes to epilepsy by disrupting proper neuronal firing sometimes in association with altered G-protein signaling components. These associations highlight GIRK1 as a valuable target for therapeutic interventions in related disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (PubMed : 8804710, PubMed : 8868049). This receptor plays a crucial role in regulating the heartbeat (By similarity).
See full target information KCNJ3

대체 명칭 보기

GIRK1, KCNJ3, G protein-activated inward rectifier potassium channel 1, GIRK-1, Inward rectifier K(+) channel Kir3.1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

eLife 4:e10150 PubMed26523391

2015

ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation.

Applications

Unspecified application

Species

Unspecified reactive species

Nataliya Nady,Ankit Gupta,Ziyang Ma,Tomek Swigut,Akiko Koide,Shohei Koide,Joanna Wysocka
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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