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AB68807

Anti-GIYD2 antibody

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Mouse Polyclonal GIYD2 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLX1A.

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SLX1A.

Q9BQ83

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보완 제품

Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

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Primary Antibodies

AB2179

Anti-Blooms Syndrome Protein Blm antibody

Immunoprecipitation - Anti-Blooms Syndrome Protein Blm antibody (AB2179)

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Primary Antibodies

AB79398

Anti-RPA70 antibody [EPR3472]

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Flow Cytometry (Intracellular) - Anti-RPA70 antibody [EPR3472] (AB79398)

  • 5
  • 6
Primary Antibodies

AB70525

Anti-BLAP75 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BLAP75 antibody (AB70525)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GIYD2 also known as GID complex subunit 2 is a protein with a molecular mass of approximately 36 kDa. This protein belongs to a family of proteins that contain the GYF domain involved in protein-protein interactions. GIYD2 shows expression in various tissues with significant presence in the brain liver and kidneys. The protein plays a role in maintaining cellular processes by potentially interacting with other proteins through its GYF domain.
Biological function summary

The GIYD2 protein functions within the GID complex which participates in the degradation of specific proteins via the ubiquitin-proteasome system. This process involves tagging target proteins with ubiquitin molecules directing them to the proteasome for degradation. The activity of GIYD2 within the complex ensures that levels of particular proteins are kept in check facilitating normal cellular functions and responses. The proper function of GIYD2 helps prevent the accumulation of dysfunctional or unnecessary proteins in the cell.

Pathways

GIYD2 interacts in the ubiquitin-mediated proteolysis pathway influencing protein turnover in the cell. Its action is related to the action of ubiquitin ligases such as UBR1 which assists in recognizing proteins marked for degradation. GIYD2 also impacts the cell cycle pathway by regulating the stability of specific cell cycle regulators linking it to proteins involved in cell division and growth such as cyclins and cyclin-dependent kinases.

GIYD2 has connections to neurodegeneration and liver diseases where protein homeostasis is disrupted. Abnormal GIYD2 function may impact levels of proteins influencing neurodegenerative disorders like Alzheimer's disease in association with proteins such as tau. In liver diseases its involvement in protein degradation may affect responses to cellular stress and damage interacting with cellular stress response elements including heat shock proteins.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
See full target information SLX1A

대체 명칭 보기

GIYD1, SLX1, SLX1B, GIYD2, SLX1A, Structure-specific endonuclease subunit SLX1, GIY-YIG domain-containing protein 1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

EMBO reports 26:1290-1314 PubMed39870965

2025

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges.

Applications

Unspecified application

Species

Unspecified reactive species

Jung Jennifer Ho,Edith Cheng,Cassandra J Wong,Jonathan R St-Germain,Wade H Dunham,Brian Raught,Anne-Claude Gingras,Grant W Brown
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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