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AB126901

Anti-GLIS3 antibody

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(1 출판물)

Rabbit Polyclonal GLIS3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GLIS3 aa 500 to C-terminus.

대체 명칭 보기

ZNF515, GLIS3, Zinc finger protein GLIS3, GLI-similar 3, Zinc finger protein 515

1 이미지
Western blot - Anti-GLIS3 antibody (AB126901)
  • WB

Unknown

Western blot - Anti-GLIS3 antibody (AB126901)

7.5% SDS PAGE

All lanes:

Western blot - Anti-GLIS3 antibody (ab126901) at 1/3000 dilution

All lanes:

U87-MG cell lysate at 30 µg

Predicted band size: 84 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human GLIS3 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8NEA6

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대체품

Primary Antibodies

AB203121

Anti-GLIS3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLIS3 antibody (AB203121)

  • 0
  • 0

보완 제품

Primary Antibodies

AB128912

Anti-HNF-1B antibody [EPR6334(2)]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HNF-1B antibody [EPR6334(2)] (AB128912)

  • 0
  • 0
Primary Antibodies

AB71559

Anti-Hes1 antibody

Western blot - Anti-Hes1 antibody (AB71559)

  • 4
  • 26
Primary Antibodies

AB316870

Anti-HNF1 alpha antibody [RM1094]

BOND RX™ Validated|20ul selling size|Recombinant|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HNF1 alpha antibody [RM1094] (AB316870)

  • 0
  • 0
Primary Antibodies

AB230822

Anti-BMAL1 antibody [EPR23696-22]

BOND RX™ Validated|RabMAb|Recombinant|Advanced Validation|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-BMAL1 antibody [EPR23696-22] (AB230822)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GLIS3 also known as GLIS family zinc finger 3 is a transcription factor with important roles in gene expression regulation. GLIS3 has a molecular mass of approximately 93 kDa. This protein is expressed in multiple tissues including the pancreas thyroid and kidney. GLIS3 contains five Kruppel-like zinc finger domains that facilitate its ability to bind to DNA and mediate transcriptional regulation.
Biological function summary

GLIS3 influences various cellular processes most notably those related to pancreatic function and insulin production. It acts as part of a transcriptional complex that modulates the expression of genes critical for beta-cell development and function. This action establishes its important role in maintaining glucose homeostasis. By binding to specific DNA sites GLIS3 regulates genes involved in producing insulin and maintaining proper endocrine pancreas function.

Pathways

GLIS3 plays integral roles in the insulin signaling and glucose metabolism pathways. It interacts with proteins such as PDX1 and NEUROD1 both of which are essential for beta-cell development and insulin gene expression. The involvement of GLIS3 in these pathways highlights its importance in glucose regulation and metabolic balance within the body.

GLIS3 has significant links with neonatal diabetes and hypothyroidism. Mutations in the GLIS3 gene can lead to congenital hypothyroidism by disrupting thyroid hormone production and regulation. Moreover GLIS3's influence on insulin production and pancreatic beta-cell function implicates it in neonatal diabetes development. Its interaction with other proteins like NEUROD1 and PDX1 further establishes its association with these metabolic and endocrine disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Acts both as a repressor and an activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).
See full target information GLIS3
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of virology 91: PubMed28768870

2017

Replication of JC Virus DNA in the G144 Oligodendrocyte Cell Line Is Dependent Upon Akt.

Applications

Unspecified application

Species

Unspecified reactive species

Jesse N Peterson,Brian Lin,Jong Shin,Paul J Phelan,Philip Tsichlis,James E Schwob,Peter A Bullock
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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