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AB188595

Anti-GLP2R antibody - N-terminal

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Rabbit Polyclonal GLP2R antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Glucagon-like peptide 2 receptor.

대체 명칭 보기

Glucagon-like peptide 2 receptor, GLP-2 receptor, GLP-2-R, GLP-2R, GLP2R

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLP2R antibody - N-terminal (AB188595)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLP2R antibody - N-terminal (AB188595)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human small intestine tissue, labeling GLP2R with ab188595 at 10 μg/ml.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Glucagon-like peptide 2 receptor. The exact immunogen used to generate this antibody is proprietary information.

O95838

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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대체품

Primary Antibodies

AB207407

Anti-GLP2R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLP2R antibody (AB207407)

  • 0
  • 0

보완 제품

Primary Antibodies

AB92517

Anti-Glucagon antibody [EP3070]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [EP3070] (AB92517)

  • 5
  • 8
Primary Antibodies

AB209792

Anti-GIP antibody [EPR20410]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant|Trial Size|Trial Size|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GIP antibody [EPR20410] (AB209792)

  • 0
  • 0
Assay Kits

AB39401

Caspase-3 Assay Kit (Colorimetric)

Functional Studies - Caspase-3 Assay Kit (Colorimetric) (AB39401)

  • 0
  • 1
Primary Antibodies

AB254352

Anti-GLP-1R antibody [EPR23507-57]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLP-1R antibody [EPR23507-57] (AB254352)

  • 1
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GLP2R also known as Glucagon-Like Peptide 2 Receptor is a G-protein coupled receptor with a mass of approximately 63 kDa. It is expressed in various tissues most notably in the small intestine colon and central nervous system. This receptor binds to glucagon-like peptide 2 (GLP-2) and plays a role in mediating intestinal growth and function. As a member of the B1 receptor family GLP2R uses adenylate cyclase to convert ATP to cAMP leading to downstream cellular effects.
Biological function summary

GLP2R modulates several functions related to gut health and integrity. It does not function as part of a larger protein complex but has significant roles when activated by its ligand GLP-2. The receptor supports intestinal epithelial growth enhances nutrient absorption and mitigates inflammatory responses in the gut lining. Additionally GLP2R activity promotes maintenance of mucosal integrity and supports a barrier against pathogens.

Pathways

GLP2R is important in the regulation of the intestinal growth pathway and nutrient absorption. It interacts with related proteins like glucagon and GLP-1 receptors which are part of the glucagon receptor family. These pathways involve processes that control gut motility secretion and cell proliferation. By mediating these signaling pathways GLP2R ensures effective gut homeostasis.

GLP2R has associations with conditions such as short bowel syndrome and inflammatory bowel disease. In short bowel syndrome GLP2R activity supports gut adaptation thereby improving nutrient absorption. In inflammatory bowel disease its role in reducing intestinal inflammation and repairing the mucosa links it to potential therapeutic targets. Connections through the disease pathways include interactions with proteins like inflammatory cytokines and growth factors which influence immune response and epithelial repair mechanisms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
See full target information Glucagon-like peptide 2 receptor
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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