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AB61054

Anti-GluA4 (phospho S862) antibody

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Rabbit Polyclonal GluA4 phospho S862 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GRIA4 pS862.
1 이미지
Western blot - Anti-GluA4 (phospho S862) antibody (AB61054)
  • WB

Unknown

Western blot - Anti-GluA4 (phospho S862) antibody (AB61054)

All lanes:

Western blot - Anti-GluA4 (phospho S862) antibody (ab61054) at 1/500 dilution

Lane 1:

extracts from HepG2 cells treated with Forskolin (40nM, 30mins)

Lane 2:

extracts from HepG2 cells treated with Forskolin (40nM, 30mins) with immunizing phosphopeptide

Predicted band size: 101 kDa

Observed band size: 102 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human GRIA4 pS862. The exact immunogen used to generate this antibody is proprietary information.

P48058

Specificity

Detects target only when phosphorylated at serine 862.

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대체품

Primary Antibodies

AB232015

Anti-GluA4 antibody [EPR2512(2)] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-GluA4 antibody [EPR2512(2)] - BSA and Azide free (AB232015)

  • 0
  • 0
Primary Antibodies

AB115322

Anti-GluA4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GluA4 antibody (AB115322)

  • 0
  • 0
Primary Antibodies

AB109431

Anti-GluA4 antibody [EPR2512(2)]

RabMAb|Recombinant|Trial Size

Flow Cytometry (Intracellular) - Anti-GluA4 antibody [EPR2512(2)] (AB109431)

  • 0
  • 0

보완 제품

Primary Antibodies

AB280206

Anti-Glutamate receptor 4 antibody [EPR24283-69] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutamate receptor 4 antibody [EPR24283-69] - BSA and Azide free (AB280206)

  • 0
  • 0
Primary Antibodies

AB251953

Anti-GRID2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRID2 antibody (AB251953)

  • 0
  • 0
Primary Antibodies

AB183797

Anti-Glutamate Receptor 1 (AMPA subtype) antibody [EPR19522]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutamate Receptor 1 (AMPA subtype) antibody [EPR19522] (AB183797)

  • 5
  • 1
Primary Antibodies

AB173297

Anti-NCAM2 antibody [EPR12815(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM2 antibody [EPR12815(B)] (AB173297)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein GluA4 also known as GluR4 or AMPA receptor subunit 4 plays a critical role in synaptic transmission. This receptor belongs to the family of ionotropic glutamate receptors which are activated by the neurotransmitter glutamate. As part of the AMPA receptor complex GluA4 contributes to the fast synaptic responses in the central nervous system. The GluA4 protein has a molecular mass of approximately 100 kDa and is prominently expressed in the brain particularly in the cerebellum and cortex although expression can vary by specific neuronal populations.
Biological function summary

GluA4 functions as an integral component of the AMPA receptor complex which mediates synaptic plasticity and strength. AMPA receptors like GluA4 facilitate the influx of sodium and calcium ions upon glutamate binding essential for long-term potentiation a cellular process playing an important role in learning and memory. GluA4 forms tetrameric complexes that co-assemble with other AMPA receptor subunits such as GluA1 GluA2 and GluA3 providing diversity in the receptor properties.

Pathways

GluA4 is embedded within the glutamatergic signaling pathways important for synaptic transmission and plasticity. It plays a part in the long-term potentiation (LTP) and long-term depression (LTD) pathways both of which involve calcium-dependent signaling cascades. These pathways often overlap with the functions of other proteins such as NMDA receptors which also bind glutamate and help regulate the same synaptic responses.

GluA4 has associations with neurological conditions like epilepsy and schizophrenia. Its dysregulation in AMPA receptor-mediated pathways may contribute to aberrant synaptic transmission observed in these disorders. GluA4 works in conjunction with other receptor subunits and related proteins like PSD-95 which further connects it to the synaptic architecture and signaling alterations seen in these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed : 21172611).
See full target information GRIA4 pS862

대체 명칭 보기

GluA4, GLUR4, GRIA4, Glutamate receptor 4, GluR-4, GluR4, AMPA-selective glutamate receptor 4, GluR-D
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cellular and molecular gastroenterology and hepatology 17:517-538 PubMed38158122

2024

Th2 Cell Activation in Chronic Liver Disease Is Driven by Local IL33 and Contributes to IL13-Dependent Fibrogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Johanna Reißing,Marie Berres,Pavel Strnad,Alexander Wree,Maria Eugenia Inzaugarat,Christian Trautwein,Tony Bruns,Henning Wolfgang Zimmermann
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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