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AB88519

Anti-GLUD2 antibody

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Mouse Polyclonal GLUD2 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GLUD2 aa 250 to C-terminus.
2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLUD2 antibody (AB88519)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLUD2 antibody (AB88519)

Immunoperoxidase staining of Human testis tissue using ab88519 at 3 μg/ml

Western blot - Anti-GLUD2 antibody (AB88519)
  • WB

Unknown

Western blot - Anti-GLUD2 antibody (AB88519)

All lanes:

Western blot - Anti-GLUD2 antibody (ab88519) at 1 µg/mL

All lanes:

Human kidney tissue lysate at 50 µg

Predicted band size: 61 kDa

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주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human GLUD2 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P49448

Specificity

Due to high sequence homology with GLUD1 there is a potential for cross-reactivity.

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보완 제품

Proteins & Peptides

AB132807

Recombinant Human GLUD2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human GLUD2 protein (GST tag N-Terminus) (AB132807)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GLUD2 also known as glutamate dehydrogenase 2 plays a critical role in the conversion of glutamate to α-ketoglutarate and ammonia facilitated by the NAD+ or NADP+ cofactor. This enzyme belongs to the family of oxidoreductases and has a molecular mass of around 62 kDa. GLUD2 is mainly expressed in the brain specifically in neurons and glial cells reflecting its significant function in central nervous system activities.
Biological function summary

GLUD2 is involved in amino acid metabolism and neurotransmitter flux. It participates in balancing nitrogen and carbon important for neurotransmitter release and energy production in neural cells. The enzyme often exists as part of signaling complexes within mitochondria emphasizing its role in cellular energy homeostasis. Through its metabolic activities GLUD2 supports synapses in maintaining cognitive functions.

Pathways

GLUD2 plays important roles in the TCA cycle and glutamine-glutamate cycle. In the TCA cycle it facilitates the entry of nitrogen into the cycle via α-ketoglutarate production directly influencing cellular respiration and ATP generation. Its activity in the glutamine-glutamate cycle links it to interactions with glutaminase affecting synaptic signaling and plasticity which are vital for neural communication.

GLUD2 has associations with neurodegenerative conditions and metabolic disorders. Its malfunction contributes to hyperinsulinism-hyperammonemia syndrome and increased risk for certain neuropathologies like Alzheimer's disease. GLUD2's relationship with proteins like glutaminase and other dehydrogenases can influence the progression of these disorders by altering metabolic fluxes.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
See full target information GLUD2

대체 명칭 보기

GLUDP1, GLUD2, GDH 2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in pharmacology 16:1518481 PubMed39931687

2025

The gut-kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Cong Han,Ran-Ran Gao,Le Zhou,Wei Li
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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