JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB272606

Anti-Glycogenin 1 antibody

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Rabbit Polyclonal Glycogenin 1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GYG1 aa 200-350.

대체 명칭 보기

GYG, GYG1, Glycogenin-1, GN-1, GN1

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-Glycogenin 1 antibody (AB272606)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Glycogenin 1 antibody (AB272606)

PFA fixed, Triton X-100 permeablized human cell line U-251 MG labeling Glycogenin 1 (green) using ab272606at 2 ug/ml in ICC/IF analysis.

Western blot - Anti-Glycogenin 1 antibody (AB272606)
  • WB

Supplier Data

Western blot - Anti-Glycogenin 1 antibody (AB272606)

All lanes:

Western blot - Anti-Glycogenin 1 antibody (ab272606) at 0.4 µg/mL

All lanes:

Human testis tissue lysate

Predicted band size: 39 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human GYG1 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

P46976

style
left-column

보완 제품

Primary Antibodies

AB314028

Anti-Glycogen synthase 1/GYS1 (phospho S641) antibody [1D1]

Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Glycogen synthase 1/GYS1 (phospho S641) antibody [1D1] (AB314028)

  • 0
  • 0
Primary Antibodies

AB96359

Anti-Glycogenin 2 antibody

Western blot - Anti-Glycogenin 2 antibody (AB96359)

  • 0
  • 0
Primary Antibodies

AB40810

Anti-Glycogen synthase 1/GYS1 antibody [EP817Y]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-Glycogen synthase 1/GYS1 antibody [EP817Y] (AB40810)

  • 4
  • 6
Primary Antibodies

AB180596

Anti-GBE1 antibody [EP11113]

RabMAb

Western blot - Anti-GBE1 antibody [EP11113] (AB180596)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Glycogenin 1 also known as GYG1 plays an essential role in the initiation of glycogen biosynthesis. This protein acts as a primer that starts glycogen formation by autoglucosylation attaching glucose residues to itself which leads to the formation of a glycogen molecule. With a molecular mass of approximately 37 kDa Glycogenin 1 is expressed widely in tissues showing high levels in skeletal muscle heart and liver. It forms a homodimer and possesses conserved surface residues necessary for its enzymatic function.
Biological function summary

Glycogenin 1 serves as the foundation for glycogen granule formation by providing the initial glucose chain that glycogen synthase can extend. The protein participates in the formation of a macromolecular complex that includes glycogen synthase and glycogen branching enzyme facilitating efficient glycogen deposition. The association with these enzymes ensures that the glycogen is structured properly optimizing cellular energy storage. Glycogenin 1 acts as the core around which all further glucose additions are built making it indispensable for maintaining energy reserves.

Pathways

Glycogenin 1 is integral to glycogen metabolism. It plays a critical role within the glycogen biosynthesis pathway closely interacting with proteins such as glycogen synthase and the branching enzyme. The coordinated activity of Glycogenin 1 glycogen synthase and the branching enzyme is necessary for the proper assembly of glycogen particles. This pathway regulation impacts glucose homeostasis and energy management in muscle and liver tissues indicating its importance for metabolic balance.

Mutations or dysfunctions in Glycogenin 1 link to glycogen storage diseases such as Glycogen Storage Disease Type XV (GSD XV). This disorder arises when an abnormal Glycogenin 1 fails to synthesize the primer glucose molecules leading to energy storage issues. The disease symptoms often resemble those seen with impaired glycogen synthase function as both proteins are involved in glycogen accumulation. Efficient glycogen synthesis disruptions highlight Glycogenin 1's therapeutic research importance in metabolic diseases.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
See full target information GYG1
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com