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AB272565

Anti-Glyt1A antibody

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(1 리뷰)

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(1 출판물)

Rabbit Polyclonal Glyt1A antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC6A9 aa 200-300.

대체 명칭 보기

Sodium- and chloride-dependent glycine transporter 1, GlyT-1, GlyT1, Solute carrier family 6 member 9, SLC6A9

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glyt1A antibody (AB272565)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glyt1A antibody (AB272565)

Paraffin-embedded formalin-fixed Human colon tissue stained for Glyt1A using ab272565 at 1/200 in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-Glyt1A antibody (AB272565)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Glyt1A antibody (AB272565)

PFA fixed, Triton X-100 permeablized human cell line U-251 MG labeling Glyt1A (green) using ab272565 at 2 ug/ml in ICC/IF analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SLC6A9 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

P48067

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보완 제품

Primary Antibodies

AB187525

Anti-D Amino Acid Oxidase antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-D Amino Acid Oxidase antibody (AB187525)

  • 4
  • 1
Primary Antibodies

AB217756

Anti-RERE antibody

Western blot - Anti-RERE antibody (AB217756)

  • 0
  • 0
Primary Antibodies

AB195393

Anti-MeCP2 antibody - ChIP Grade

ChIP - Anti-MeCP2 antibody - ChIP Grade (AB195393)

  • 0
  • 0
Assay Kits

AB102517

Glucose Assay Kit - reducing agent compatible

Functional Studies - Glucose Assay Kit - reducing agent compatible (AB102517)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Glyt1A also known as Glycine Transporter 1 or SLC6A9 functions mechanically by mediating the reuptake of glycine in synaptic clefts. This transport process plays a significant role in regulating glycine levels within the central nervous system. Glyt1A exhibits a molecular mass of approximately 70 kDa. Expression of Glyt1A is noted in both the central nervous system and various peripheral tissues. The distribution pattern supports its involvement in neurotransmission and glycine modulation in different tissue types.
Biological function summary

Glyt1A contributes to regulating neurotransmitter balance by removing excess glycine from synaptic spaces. By doing so it ensures proper synaptic functioning and neurotransmission. Glyt1A can form part of larger transporter complexes that modulate synaptic activities and neurotransmitter levels. Its function is tightly linked with its ability to transport glycine which influences N-methyl-D-aspartate (NMDA) receptor activity due to the co-agonist role of glycine in NMDA receptor activation.

Pathways

Glyt1A plays a part in neurotransmission pathways particularly impacting glutamatergic signaling. The transporter regulates glycine concentration which affects NMDA receptor activity an important receptor in excitatory neurotransmission and synaptic plasticity. Its activity is closely associated with proteins involved in the glutamatergic pathway such as NMDA receptors and other neurotransmitter transporters including the GLT-1 glutamate transporter.

Glyt1A associates with neurological disorders like schizophrenia and glycine encephalopathy. In schizophrenia altered glycine transport can affect NMDA receptor functionality influencing symptoms and disease progression. Glyt1A interacts with NMDA receptor pathways which link to the pathophysiology of schizophrenia. In glycine encephalopathy also known as non-ketotic hyperglycinemia the dysregulation of glycine transport leads to toxic levels of glycine impacting neurological development and function.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Sodium- and chloride-dependent glycine transporter (PubMed : 8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses.. Isoform GlyT-1B. Sodium- and chloride-dependent glycine transporter.. Isoform GlyT-1C. Sodium- and chloride-dependent glycine transporter.
See full target information SLC6A9
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Histology and histopathology 37:461-474 PubMed35060113

2022

Lidocaine represses the malignant behavior of lung carcinoma cells via the circ_PDZD8/miR-516b-5p/GOLT1A axis.

Applications

Unspecified application

Species

Unspecified reactive species

Huafen Zi,Li Chen,Qian Ruan
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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