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AB236095

Anti-GNA14 antibody

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Rabbit Polyclonal GNA14 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GNA14 aa 1-350.

대체 명칭 보기

Guanine nucleotide-binding protein subunit alpha-14, G alpha-14, G-protein subunit alpha-14, GNA14

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNA14 antibody (AB236095)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNA14 antibody (AB236095)

Paraffin-embedded human prostate cancer tissue stained for GNA14 using ab236095 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human GNA14 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

O95837

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보완 제품

Primary Antibodies

AB205270

Anti-active YAP1 antibody [EPR19812]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-active YAP1 antibody [EPR19812] (AB205270)

  • 5
  • 25
Primary Antibodies

AB98887

Anti-Rhodopsin antibody [Rho 4D2]

Immunohistochemistry (Frozen sections) - Anti-Rhodopsin antibody [Rho 4D2] (AB98887)

  • 5
  • 3
Proteins & Peptides

AB268598

Recombinant human GNA14 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant human GNA14 protein (Tagged) (AB268598)

  • 0
  • 0
Primary Antibodies

AB76252

Anti-YAP1 (phospho S127) antibody [EP1675Y]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-YAP1 (phospho S127) antibody [EP1675Y] (AB76252)

  • 4
  • 3
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GNA14 also known as Guanine nucleotide-binding protein subunit alpha-14 is a component of the G protein family. This protein has a mass of approximately 41 kDa. It primarily expresses in the liver adrenal glands placenta and spleen. As a G protein it plays a role in signal transduction as part of the G alpha subunit which is an important player in relaying signals from cell surface receptors to downstream effectors within the cell.
Biological function summary

GNA14 mediates signal transduction by coupling with cell surface receptors to activate downstream signaling pathways. It functions as part of the larger heterotrimeric G protein complex interacting with G protein-coupled receptors (GPCRs). These GPCRs stimulate GNA14 which then activates intracellular signaling paths involved in various cellular responses including growth differentiation and metabolism playing an important role in maintaining cellular homeostasis.

Pathways

GNA14 participates mainly in the phospholipase C (PLC) signaling pathway where it interacts with PLC to regulate calcium ion release within the cells. This ion release affects various cellular processes such as muscle contraction and neurotransmitter release. GNA14 also shares pathway involvement with proteins like GNA13 another member of the G alpha subunit family which can have overlapping or distinct physiological roles.

GNA14 mutations have associations with conditions like uveal melanoma and Kaposiform hemangioendothelioma. In uveal melanoma GNA14 mutations affect normal signaling pathways leading to uncontrolled cell proliferation. In these diseases GNA14 does not work alone but interacts with other proteins involved in cancer pathway dysregulations such as GNAQ and BRAF implicating a complex network of molecular interactions in the pathology of such disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
See full target information GNA14
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 16:7248 PubMed40769964

2025

IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jan-Inge Bjune,Samantha Laber,Laurence Lawrence-Archer,Patrizia M C Nothnagel,Shuntaro Yamada,Xu Zhao,Pouda Panahandeh Strømland,Niyaz Al-Sharabi,Kamal Mustafa,Pål R Njølstad,Melina Claussnitzer,Roger D Cox,Pierre Chymkowitch,Gunnar Mellgren,Simon N Dankel
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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