AB238868

Anti-GNG4 antibody

Be the first to review this product! 리뷰 제출

(3 제품이 사용된 논문 )

Rabbit Polyclonal GNG4 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GNG4.

대체 명칭 보기

GNGT4, GNG4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG4 antibody (AB238868)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG4 antibody (AB238868)

Paraffin-embedded human pancreas tissue stained for GNG4 using ab238868 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG4 antibody (AB238868)

Paraffin-embedded human kidney tissue stained for GNG4 using ab238868 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-GNG4 antibody (AB238868)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GNG4 antibody (AB238868)

HepG2 (Human liver hepatocellular carcinoma cell line) cells stained for GNG4 (green) using ab238868 at 1/100 dilution in ICC/IF. Secondary antibody is an Alexa-Fluor^® 488-conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human GNG4.

P50150

style

left-column

style

left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

style

left-column

style

left-column

특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity greater than 95%.

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

style

left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The G-protein gamma subunit 4 also known as GNG4 is a component of the heterotrimeric G-protein complex. It has a molecular mass of approximately 7.9 kDa. This protein is typically expressed in various tissues including the brain and spinal cord. Functionally GNG4 is involved in signal transduction processes by forming a complex with the G-protein beta subunit playing a critical role in transmitting signals from G-protein-coupled receptors (GPCRs) to downstream effectors.

Biological function summary

GNG4 participates in the modulation of intracellular signal pathways. It forms an integral part of the G-protein complex which includes another subunit known as GNB1. This complex is necessary for proper functioning of GPCR-mediated signaling. The G-protein complex influences various cellular responses by affecting ion channels enzymes and other intracellular pathways. The presence of GNG4 in neuronal tissues suggests its role in neurotransmission and the potential influence on neurologic function.

Pathways

GNG4 plays a role in the adenylyl cyclase signaling pathway and the phospholipase C pathway. In both pathways GNG4 together with GNB1 regulates the conversion of extracellular signals into intracellular actions. These actions include cyclic AMP production or calcium ion release which subsequently affect cellular activities. This involvement links GNG4 to various cellular processes by mediating inputs from diverse signals through its interaction with GPCR-related pathways.

GNG4 is associated with conditions such as neuropsychiatric disorders and cancer. The aberrant expression or mutation of GNG4 can disrupt normal signaling pathways contributing to disease pathology. In neuropsychiatric disorders GNG4 interacts with dopamine receptor pathways affecting dopaminergic signaling; this connection suggests a possible link to conditions like schizophrenia. In cancer altered GNG4 expression has been observed in some tumor types indicating its potential involvement in tumorigenesis through signaling pathways linked to other proteins such as Ras.

style

left-column

style

left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

타겟 정보

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

See full target information GNG4

style

left-column

제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Bioengineered 12:7849-7858 PubMed34635014

2021

MicroRNA miR-19b-3p mediated G protein γ subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xia Zhao,Xiang-Cheng Zhang,Kui Zang,Zhi-Hao Yu

Molecular medicine reports 24: PubMed34080026

2021

HIGD‑1B inhibits hypoxia‑induced mitochondrial fragmentation by regulating OPA1 cleavage in cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Pang,Zhide Zhu,Zhihao Wen,Junshen Lu,Hao Lin,Meiling Tang,Zhiliang Xu,Jianqi Lu

Oncology letters 20:334 PubMed33123245

2020

Molecular heterogeneity of guanine nucleotide binding-protein γ subunit 4 in left- and right-sided colon cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jintian Song,Jianwei Yang,Rongbo Lin,Xiongchao Cai,Liang Zheng,Yigui Chen

제품이 사용된 논문 모두 보기

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GNG4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG4 antibody (AB238868)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG4 antibody (AB238868)

Immunocytochemistry/ Immunofluorescence - Anti-GNG4 antibody (AB238868)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise