AB204594

Anti-GNLY/Granulysin antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal GNLY/Granulysin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GNLY aa 1-100.

대체 명칭 보기

LAG2, NKG5, TLA519, GNLY, Granulysin, Lymphokine LAG-2, Protein NKG5, T-cell activation protein 519

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody (AB204594)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody (AB204594)

Paraffin embedded human endometrium tissue stained for GNLY/Granulysin using ab204594 at 1/2500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody (AB204594)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody (AB204594)

Paraffin embedded human pancreas tissue stained for GNLY/Granulysin using ab204594 at 1/2500 dilution in immunohistochemical analysis. Shows no positivity in exocrine glandular cells as expected.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody (AB204594)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody (AB204594)

Paraffin embedded human lymph node tissue stained for GNLY/Granulysin using ab204594 at 1/2500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody (AB204594)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody (AB204594)

Paraffin embedded human spleen tissue stained for GNLY/Granulysin using ab204594 at 1/2500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody (AB204594)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody (AB204594)

Paraffin embedded human skeletal muscle tissue stained for GNLY/Granulysin using ab204594 at 1/2500 dilution in immunohistochemical analysis. Shows no positivity in myocytes cells as expected.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

Immunogen

Recombinant Fragment Protein within Human GNLY aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

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대체품

Primary Antibodies

AB241511

Anti-GNLY/Granulysin antibody [EPR22110-101] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNLY/Granulysin antibody [EPR22110-101] - BSA and Azide free (AB241511)

0
0

Primary Antibodies

AB223326

Anti-GNLY/Granulysin antibody [EPR22110-128]

RabMAb|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-GNLY/Granulysin antibody [EPR22110-128] (AB223326)

0
0

Primary Antibodies

AB241333

Anti-GNLY/Granulysin antibody [EPR22110-101]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-GNLY/Granulysin antibody [EPR22110-101] (AB241333)

0
0

Primary Antibodies

AB238460

Anti-GNLY/Granulysin antibody [EPR22110-128] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-GNLY/Granulysin antibody [EPR22110-128] - BSA and Azide free (AB238460)

0
0

보완 제품

Primary Antibodies

AB282703

Anti-Granzyme K antibody [EPR24601-164]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Granzyme K antibody [EPR24601-164] (AB282703)

0
0

Primary Antibodies

AB314293

APC Anti-CXCR3 antibody [EPR23845-44]

RabMAb|Recombinant

Flow Cytometry - APC Anti-CXCR3 antibody [EPR23845-44] (AB314293)

0
0

Primary Antibodies

AB255598

Anti-Granzyme B antibody [EPR22645-206]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Granzyme B antibody [EPR22645-206] (AB255598)

4
3

Primary Antibodies

AB260035

Anti-NKG2A antibody [EPR23737-127]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Multiplex immunohistochemistry - Anti-NKG2A antibody [EPR23737-127] (AB260035)

5
1

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Granulysin also known as GNLY is a cytolytic protein with a mass of approximately 9 kDa present in the granules of cytotoxic T lymphocytes and natural killer cells. This protein expressed in activated human immune cells plays a role in immune defense by creating pores in the target cell membranes which enables other cytotoxic molecules to enter and induce cell death. Researchers often utilize Granulysin as a GNLY marker to assess immune cell activity within the body.

Biological function summary

Granulysin contributes to the body's defense against bacterial fungal and parasitic infections. It acts independently but can also collaborate with other immune components to enhance its effects. Granulysin disrupts microbial membranes owing to its affinity to negatively charged lipids leading to pathogen elimination. This mechanism plays a critical role in the human body's broader immune response.

Pathways

Granulysin operates significantly within the immune response pathway by working in concert with perforin another cytolytic protein. Together they form a potent immune mechanism aimed at eliminating infected or malignant cells. Furthermore the interferon-gamma pathway closely influences Granulysin suggesting a connection to innate and adaptive immune responses.

Granulysin shows association with various conditions most notably tuberculosis and leprosy. In these diseases the GNLY protein levels reflect the body's immune activity against the pathogens. Granulysin works alongside proteins such as perforin and granzymes whose involvement suggests possible diagnostic markers for understanding the immune response in these bacterial infections.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.

See full target information GNLY

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Acta physiologica (Oxford, England) 236:e13857 PubMed35753051

2022

The highly expressed calcium-insensitive synaptotagmin-11 and synaptotagmin-13 modulate insulin secretion.

Applications

Unspecified application

Species

Unspecified reactive species

Jones K Ofori,Alexandros Karagiannopoulos,Mohammad Barghouth,Mototsugu Nagao,Markus E Andersson,Vishal A Salunkhe,Enming Zhang,Anna Wendt,Lena Eliasson

International journal of clinical and experimental 12:1634-1641 PubMed31933981

2019

Increased granulysin in the peripheral blood and tissues of patients with oral lichen planus.

Applications

Unspecified application

Species

Unspecified reactive species

Juanyong Xu,Lin Liu,Jing Shan,Shan Li,Chen Shen,Chen Wang,Yuan Fan

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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