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AB238876

Anti-GOLPH3L antibody

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Rabbit Polyclonal GOLPH3L antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GOLPH3L aa 1 to C-terminus.

대체 명칭 보기

GPP34R, GOLPH3L, Golgi phosphoprotein 3-like, GPP34-related protein

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLPH3L antibody (AB238876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLPH3L antibody (AB238876)

Paraffin-embedded human colon cancer tissue stained for GOLPH3L with ab238876 at a 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLPH3L antibody (AB238876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLPH3L antibody (AB238876)

Paraffin-embedded human melanoma tissue stained for GOLPH3L with ab238876 at a 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human GOLPH3L aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9H4A5

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보완 제품

Primary Antibodies

AB98023

Anti-GOLPH3/MIDAS antibody

Immunocytochemistry/ Immunofluorescence - Anti-GOLPH3/MIDAS antibody (AB98023)

  • 5
  • 2
Primary Antibodies

AB238875

Anti-LY6H antibody

Immunocytochemistry/ Immunofluorescence - Anti-LY6H antibody (AB238875)

  • 0
  • 0
Primary Antibodies

AB176689

Anti-ZNF384 antibody

Immunoprecipitation - Anti-ZNF384 antibody (AB176689)

  • 5
  • 1
Primary Antibodies

AB237050

Anti-CBWD2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CBWD2 antibody (AB237050)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GOLPH3L also known as Golgi phosphoprotein 3-like is a protein with a molecular mass of approximately 34 kDa. This protein is located in the Golgi apparatus within cells where it plays a significant role in maintaining the Golgi's structure and function. It is expressed across various human tissues though its concentration varies suggesting its differential involvement based on cellular context and function.
Biological function summary

Proteins like GOLPH3L are engaged in the regulation of secretory pathways. While GOLPH3L does not form a complex on its own it shares functional similarities with GOLPH3 which is part of larger protein interactions within the Golgi apparatus. These proteins are believed to modulate the vesicular transport that is important for cellular trafficking and protein sorting.

Pathways

Scientists have identified GOLPH3L as a component of the PI3K/AKT/mTOR signaling pathway impacting cellular growth and metabolism. This pathway is vital for cell survival and proliferation with GOLPH3L interacting with components such as GOLPH3 to influence these processes. Furthermore this protein can impact the secretory pathway by altering Golgi-mediated transport linking it to broader physiological mechanisms.

GOLPH3L's function connects to certain cancers and neurological conditions. Variations in its expression and activity may contribute to the progression of conditions like glioblastoma where PI3K/AKT/mTOR pathway dysregulation is common. Researchers have shown that interaction with GOLPH3 can exacerbate these effects highlighting its potential role in disease progression and as a target for therapeutic interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.
See full target information GOLPH3L
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

iScience 25:105358 PubMed36339256

2022

Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non-small-cell lung carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Hyoung-Oh Jeong,Hayoon Lee,Hyemin Kim,Jinho Jang,Seunghoon Kim,Taejoo Hwang,David Whee-Young Choi,Hong Sook Kim,Naeun Lee,Yoo Mi Lee,Sehhoon Park,Hyun Ae Jung,Jong-Mu Sun,Jin Seok Ahn,Myung-Ju Ahn,Keunchil Park,Semin Lee,Se-Hoon Lee
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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