AB238002

Anti-GP2 antibody [GP2/1805]

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Mouse Monoclonal GP2 antibody. Suitable for IHC-P, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Pancreatic secretory granule membrane major glycoprotein GP2 aa 1-200.

대체 명칭 보기

Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75, GP2

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GP2 antibody [GP2/1805] (AB238002)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GP2 antibody [GP2/1805] (AB238002)

Formalin-fixed, paraffin-embedded human pancreas tissue stained for GP2 using ab238002 at 2 μg/ml in immunohistochemical analysis.

Protein Array - Anti-GP2 antibody [GP2/1805] (AB238002)

Protein Array

Unknown

Protein Array - Anti-GP2 antibody [GP2/1805] (AB238002)

ab238002 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

GP2/1805

Isotype

IgG2c

Light chain 타입

kappa

Carrier free

Reacts with

Human

Applications

IHC-P, Protein Array

applications

Immunogen

Recombinant Fragment Protein within Human Pancreatic secretory granule membrane major glycoprotein GP2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P55259

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ProteinArray" : {"fullname" : "Protein Array", "shortname":"Protein Array"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p>Incubate with primary antibody for 30 minutes at RT.</p>", "ProteinArray-species-checked": "guaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "" }, "Recombinant full length protein - Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ProteinArray-species-checked": "testedAndGuaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A/G

Purification 관련 사항

Purified from Bioreactor Concentrate by Protein A/G.

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GP2 also known as Glycoprotein 2 is an important protein with a molecular mass of about 78 kDa. It mainly expresses in pancreatic acinar cells and the epithelial cells of the gastrointestinal tract. GP2 is anchored to the zymogen granule membrane through a glycosylphosphatidylinositol (GPI) anchor which facilitates its release into the lumen. It plays a mechanical role in the stabilization and release of digestive enzymes contributing to proper digestive processes.

Biological function summary

GP2 interacts with the innate immune system by binding to pathogens such as bacteria. It forms part of the mucosal defense system within the gastrointestinal tract. GP2 acts by trapping pathogens marking them for further immune processing. It also associates with membrane proteins like lactoferrin that help modulate immune response. Through its involvement in pathogen recognition and response GP2 supports a healthy gut environment and prevents infections.

Pathways

GP2 participates in immune-related processes and pathways. One significant pathway includes the mannose-binding lectin (MBL) pathway where GP2 works together with lectins and complement proteins to mediate the identification and clearance of pathogens. GP2's interactions with the complement system overlap with proteins like C3 linking it to a broader immune surveillance network. These interactions position GP2 as a pivotal component in maintaining gut mucosal immunity.

Impaired GP2 function associates with inflammatory bowel disease (IBD) and pancreatitis. Altered expression or mutation of GP2 may compromise defensive capabilities in the gut leading to chronic inflammation as seen in Crohn's disease or ulcerative colitis. Additionally improper GP2 function can result in pancreatitis a condition where enzymes prematurely activate and damage the pancreas. In both disorders GP2’s connection to proteins involved in immune pathways such as lactoferrin and C3 highlights its importance in protecting against excessive inflammation.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.

See full target information Pancreatic secretory granule membrane major glycoprotein GP2

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

BMC oral health 24:418 PubMed38580938

2024

The metabolic reprogramming of γ-aminobutyrate in oral squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shi-Lian Wu,Guang-Yu Zha,Ke-Bin Tian,Jun Xu,Ming-Guo Cao

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GP2 antibody [GP2/1805]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GP2 antibody [GP2/1805] (AB238002)

Protein Array - Anti-GP2 antibody [GP2/1805] (AB238002)

주요 정보

Host species

Clonality

Clone number

Isotype

Light chain 타입

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise