AB219786

Anti-GPCR GPR3 antibody - Extracellular domain

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Rabbit Polyclonal GPCR GPR3 antibody. Extracellular domain. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR3.

대체 명칭 보기

ACCA, GPR3, G-protein coupled receptor 3, ACCA orphan receptor

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR3 antibody - Extracellular domain (AB219786)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR3 antibody - Extracellular domain (AB219786)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human ovary carcinoma tissue labeling GPCR GPR3 with ab219786 at 6 μg/mL.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR3 antibody - Extracellular domain (AB219786)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human brain, neurons and glia tissue labeling GPCR GPR3 with ab219786 at 6 μg/mL.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GPR3. The exact immunogen used to generate this antibody is proprietary information.

P46089

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "6 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.4 Preservative: 0.099% Sodium azide Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GPR3 also known as G protein-coupled receptor 3 is a member of the GPCR family. This receptor weighs approximately 37 kDa and exists in the cell plasma membrane where it triggers intracellular signaling pathways by interacting with G proteins. Expressed widely in the central nervous system GPR3 plays a mechanical role by activating adenylate cyclase and increasing cyclic AMP (cAMP) levels without any ligand binding a unique characteristic of this receptor.

Biological function summary

The function of GPR3 influences neural processes through its regulation of cAMP signaling. GPR3 is notably a part of signaling cascades within neuronal tissues and impacts processes such as neurogenesis and synaptic transmission. The receptor does not act alone; cooperation with other proteins in cAMP-independent pathways suggests possible involvement in broader complexes affecting brain function.

Pathways

GPR3 contributes significantly to the modulation of signaling via pathways like the cAMP/PKA pathway and may overlap or interact with the Wnt signaling pathway. These pathways include proteins like adenylate cyclase which GPR3 activates playing roles in cellular communication and signal transduction. Through these systems GPR3 impacts various physiological processes especially in the central nervous system intertwining with additional GPCR family members and intracellular signaling proteins.

GPR3 reveals links to Alzheimer's disease and depression potentially due to its regulation of cAMP and related impacts on brain function. The receptor's interaction with proteins in these conditions suggests a possible contribution to disease pathology. Specifically its relationship with beta-amyloid proteins in Alzheimer's elucidates a connection of GPR3 to neurodegenerative pathways. Similarly altered GPR3 function and its effects on serotonin pathways provide insights into depression mechanisms and therapies.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Constitutively active G-protein coupled receptor that maintains high cAMP levels and contributes to several processes, including meiotic arrest in oocytes and neuronal development, through activation of intracellular signaling pathways. Essential activator of thermogenic adipocytes, where it drives thermogenesis via constitutive G(s)-coupling activity in the absence of ligand (PubMed : 34048700). May be activated by lipid-derived agonists such as oleoylethanolamide (OEA), oleic acid or sphingosine 1-phosphate leading to activation of the G(s)/cAMP/PKA signaling pathway (PubMed : 12220620, PubMed : 38376112, PubMed : 38287117). Plays a potential role in modulating brain functions, including behavioral responses to stress and amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granule neurons via PKA, ERK, and PI3K-mediated signaling pathways (By similarity).

See full target information GPR3

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

JCI insight 6: PubMed34032636

2021

T-bet+CD27+CD21- B cells poised for plasma cell differentiation during antibody-mediated rejection of kidney transplants.

Applications

Unspecified application

Species

Unspecified reactive species

Kevin Louis,Elodie Bailly,Camila Macedo,Louis Lau,Bala Ramaswami,Alexander Chang,Uma Chandran,Douglas Landsittel,Xinyan Gu,Geetha Chalasani,Adriana Zeevi,Parmjeet Randhawa,Harinder Singh,Carmen Lefaucheur,Diana Metes

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GPCR GPR3 antibody - Extracellular domain

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR3 antibody - Extracellular domain (AB219786)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR3 antibody - Extracellular domain (AB219786)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise