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AB140783

Anti-GPCR GPR85 antibody - Extracellular domain

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Rabbit Polyclonal GPCR GPR85 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR85.

대체 명칭 보기

SREB2, GPR85, Probable G-protein coupled receptor 85, Super conserved receptor expressed in brain 2

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR85 antibody - Extracellular domain (AB140783)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR85 antibody - Extracellular domain (AB140783)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain tissue (neuron of putamen area) labelling GPCR GPR85 with ab140783 at 5.5 µg/ml.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GPR85. The exact immunogen used to generate this antibody is proprietary information.

P60893

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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대체품

Primary Antibodies

AB188781

Anti-GPCR GPR85 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR85 antibody - C-terminal (AB188781)

  • 0
  • 0

보완 제품

Primary Antibodies

AB233299

Anti-SIGLEC14 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC14 antibody (AB233299)

  • 0
  • 0
Proteins & Peptides

AB162723

Recombinant Human GPCR GPR85 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human GPCR GPR85 protein (GST tag N-Terminus) (AB162723)

  • 0
  • 0
Primary Antibodies

AB198799

Anti-Ceramide synthase 1/LAG1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ceramide synthase 1/LAG1 antibody (AB198799)

  • 0
  • 0
Primary Antibodies

AB122280

Anti-ADAT2 antibody

Immunocytochemistry - Anti-ADAT2 antibody (AB122280)

  • 3
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5.5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Lizard": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pufferfish": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Turkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Zebrafish": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The GPCR GPR85 also known as Super Conserved Receptor Expressed in the Brain 2 (SREB2) is a G-protein coupled receptor. It weighs approximately 43 kilodaltons. GPR85 is mostly expressed in the central nervous system especially in areas such as the cerebral cortex and hippocampus. The structure of GPCRs including GPR85 enables these receptors to extend across the cell membrane seven times which allows them to transmit signals from extracellular space into the cell.
Biological function summary

GPR85 plays a role in modulating neuronal signal transduction. It is part of the family of GPCRs that connects external signal molecules to internal cellular responses. Though GPR85 does not form multi-protein complexes often it influences neuronal functions and developmental processes. Its signaling can affect neurotransmitter release impacting brain function and neural connectivity.

Pathways

Researchers place GPR85 in pathways related to neurodevelopment and synaptic transmission. GPR85 involves itself in the GPCR signaling pathway and neuroactive ligand-receptor interaction path. It relates to proteins like GPR84 and other GPCRs sharing signaling mechanisms that influence brain physiology. GPR85 can carry out vital functions that connect extracellular signals with intracellular activities important for neuronal health.

Scientists associate GPR85 with schizophrenia and cognitive disorders. Alterations in GPR85 expression or function may contribute to these conditions potentially disrupting normal neural signaling and connectivity. GPR85 might interact with proteins such as GPR88 which are also involved in cognitive functions suggesting a complex network of GPCRs in maintaining proper mental health. Understanding these interactions helps in developing therapeutic approaches for brain-related disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Orphan receptor.
See full target information GPR85
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of clinical investigation 128:5235-5250 PubMed30204129

2018

HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk.

Applications

Unspecified application

Species

Unspecified reactive species

Yingying Wang,Xiaoling Weng,Luoyang Wang,Mingang Hao,Yue Li,Lidan Hou,Yu Liang,Tianqi Wu,Mengfei Yao,Guowen Lin,Yiwei Jiang,Guohui Fu,Zhaoyuan Hou,Xiangjun Meng,Jinsong Lu,Jianhua Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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