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AB129879

Anti-GPR 139 antibody

5

(1 리뷰)

|

(1 출판물)

Rabbit Polyclonal GPR 139 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR139.

대체 명칭 보기

GPRG1, PGR3, GPR139, Probable G-protein coupled receptor 139, G(q)-coupled orphan receptor GPRg1, G-protein-coupled receptor PGR3

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-GPR 139 antibody (AB129879)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GPR 139 antibody (AB129879)

ab129879 at 1/100 dilution staining GPR 139 in LOVO cells by Immunofluroescence. The image on the right is treated with the synthesised peptide

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human GPR139. The exact immunogen used to generate this antibody is proprietary information.

Q6DWJ6

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대체품

Primary Antibodies

AB155983

Anti-GPR 139 antibody [EPR10766]

RabMAb|Recombinant

Western blot - Anti-GPR 139 antibody [EPR10766] (AB155983)

  • 0
  • 0

보완 제품

Primary Antibodies

AB39742

Anti-G-protein coupled receptor 30 antibody

Western blot - Anti-G-protein coupled receptor 30 antibody (AB39742)

  • 3
  • 11
Primary Antibodies

AB126538

Anti-LOX 1 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LOX 1 antibody (AB126538)

  • 0
  • 0
Biochemicals

AB120123

Aminoguanidine hydrochloride, NOS inhibitor

Chemical Structure - Aminoguanidine hydrochloride, NOS inhibitor (AB120123)

  • 0
  • 0
Primary Antibodies

AB24233

Anti-MC4-R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC4-R antibody (AB24233)

  • 4
  • 18
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab129879 is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
보관 버퍼
pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GPR139 known also as G protein-coupled receptor 139 is a member of the rhodopsin family of G protein-coupled receptors (GPCRs). It has an approximate mass of 37 kDa. This receptor mainly expresses in the central nervous system specifically in the thalamus habenula and hypothalamus. It is part of the larger group of products encoded by GPCR genes which play significant roles in signal transduction across cell membranes.
Biological function summary

GPR139 acts as a modulator within the brain's neurochemical network. Although not part of a larger complex it influences neurotransmitter systems by transducing extracellular signals through intramembrane effects affecting physiological processes like mood circadian rhythms and pain perception. Researchers continue to explore its ligands such as L-tryptophan and L-phenylalanine which may provide further insight into its specific regulatory roles.

Pathways

The functionality of GPR139 intersects with neuronal signaling pathways like the cAMP signaling pathway. This pathway impacts cellular processes by modulating enzymes and transcription factors relevant to intracellular signaling. GPR139's activity also relates to that of other GPCRs such as GPR88 which influences similar neurological functions and developmental pathways in neurons.

GPR139 is mainly associated with neurological disorders and mental health conditions. Some studies link it to addiction and schizophrenia as it interacts with systems that regulate mood and reward. Through its association with dopamine D2 receptors GPR139 might influence disorders related to dopaminergic function offering a potential target for therapeutic interventions in these areas.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
See full target information GPR139
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecules (Basel, Switzerland) 25: PubMed33081083

2020

A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Romain Duroux,Anne Mandeau,Gaelle Guiraudie-Capraz,Yannick Quesnel,Estelle Loing
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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