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AB92796

Anti-GPR 174 antibody

5

(1 리뷰)

|

(3 제품이 사용된 논문 )

Rabbit Polyclonal GPR 174 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GPR174.
2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-GPR 174 antibody (AB92796)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GPR 174 antibody (AB92796)

ab92796 at 1/500 dilution staining GPR 174 in LOVO cells (1) without blocking peptide and (2) with blocking peptide, by immunofluorescence.

Western blot - Anti-GPR 174 antibody (AB92796)
  • WB

Unknown

Western blot - Anti-GPR 174 antibody (AB92796)

All lanes:

Western blot - Anti-GPR 174 antibody (ab92796) at 1/500 dilution

Lane 1:

Extract from K562 cells at 30 µg with no blocking peptide

Lane 2:

Extract from K562 cells at 30 µg with blocking peptide

Predicted band size: 39 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human GPR174. The exact immunogen used to generate this antibody is proprietary information.

Q9BXC1

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대체품

Primary Antibodies

AB136271

Anti-GPR 174 antibody

  • 0
  • 0

보완 제품

Primary Antibodies

AB52492

Anti-ALDH1A1 antibody [EP1933Y] - C-terminal

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-ALDH1A1 antibody [EP1933Y] - C-terminal (AB52492)

  • 4
  • 22
Primary Antibodies

AB37415

Rabbit IgG, polyclonal - Isotype Control

Flow Cytometry - Rabbit IgG, polyclonal - Isotype Control (AB37415)

  • 0
  • 0
Primary Antibodies

AB134811

Anti-GPCR GPR34 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR34 antibody (AB134811)

  • 0
  • 0
Primary Antibodies

AB181854

Anti-TEMT antibody [EPR13240]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-TEMT antibody [EPR13240] (AB181854)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
The antibody was affinity purified from rabbit antiserum by affinity chromatography using an epitope specific immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GPR174 also referred to as G protein-coupled receptor 174 is a membrane protein involved in various physiological processes. It belongs to the GPCR family characterized by its seven transmembrane domains. GPR174 has a predicted mass of approximately 40 kDa. Its expression levels are found prominently in immune cells particularly in lymphoid tissues. The receptor's specific ligands remain largely unknown though it responds to certain purine derivatives and lysophosphatidylserines acting as GPR activators in its function.
Biological function summary

GPR174 plays a role in immune cell regulation and movement. It contributes to the immune response by influencing lymphocyte positioning and proliferation. The protein facilitates cellular signaling cascades although it is not a part of larger protein complexes. Through signaling GPR174 assists in maintaining immune homeostasis highlighting its importance in adaptive and innate immune functions.

Pathways

GPR174 is integrated into the G protein-coupled signaling pathway as well as the lysophospholipid signaling pathway. Its activity influences downstream signals that affect cell migration and immune responses. Related to these pathways GPR174 interacts with other proteins like Gαi and downstream effectors ensuring signal transduction for cellular responses. These interactions and pathways highlight its role in modulating immune cell behavior.

Altered expression or aberrant signaling of GPR174 has associations with autoimmune diseases such as multiple sclerosis and lupus. Changes in the receptor's function can disrupt normal immune function leading to pathogenesis. GPR174's interaction with immune-related proteins like chemokines can exacerbate or mitigate symptoms of these conditions making it a potential therapeutic target for treatments aiming to restore immunological balance.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed : 36823105). Plays a negative role in regulatory T-cell accumulation and homeostasis. Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response. Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells. Mechanistically, acts via G(s)-containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling. Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions. Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells. Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells.
See full target information GPR174

대체 명칭 보기

FKSG79, GPCR17, GPR174, Probable G-protein coupled receptor 174
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of translational medicine 23:438 PubMed40229851

2025

The LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Xiao,Pei Xu,Xiangyuan Li,Feng Shen,Shuangfen Tao,Xiaocen Zhu,Yu Cai,Zhuowei Feng,Zhiyi Liu,Haibo Xiao,Fangbao Ding,Meiling Zhu

Frontiers in cell and developmental biology 8:568304 PubMed33763412

2021

Upregulation of Extracellular Vesicles-Encapsulated miR-132 Released From Mesenchymal Stem Cells Attenuates Ischemic Neuronal Injury by Inhibiting Smad2/c-jun Pathway Acvr2b Suppression.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Feng,Lei Meng,Liming Luan,Zhihao Fang,Peng Zhao,Guangyu Zhao

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 68:945-955 PubMed31444514

2019

Anti-angiogenic and anti-inflammatory effects of CD200-CD200R1 axis in oxygen-induced retinopathy mice model.

Applications

Unspecified application

Species

Unspecified reactive species

Yaguang Hu,Ting Wei,Shan Gao,Qiaochu Cheng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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