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AB122814

Anti-GPR123 antibody

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(1 출판물)

Rabbit Polyclonal GPR123 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ADGRA1 aa 350-500.

대체 명칭 보기

GPR123, KIAA1828, ADGRA1, Adhesion G protein-coupled receptor A1, G-protein coupled receptor 123

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR123 antibody (AB122814)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR123 antibody (AB122814)

ab122814, at 1/50 dilution, staining GPR123 in formalin-fixed, paraffin-embedded Human testis tissue by immunohistohemistry.

Immunocytochemistry/ Immunofluorescence - Anti-GPR123 antibody (AB122814)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GPR123 antibody (AB122814)

ab122814, at 4μg/ml, staining GPR123 in U-2 OS cells by immunofluorescence.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ADGRA1 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.

Q86SQ6

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보완 제품

Primary Antibodies

AB7349

Anti-Myelin Basic Protein antibody [12] - Oligodendrocyte Marker

BOND RX™ Validated|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myelin Basic Protein antibody [12] - Oligodendrocyte Marker (AB7349)

  • 4
  • 23
Primary Antibodies

AB254773

Anti-ITIH2/SHAP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITIH2/SHAP antibody (AB254773)

  • 5
  • 1
Primary Antibodies

AB109186

Anti-Olig2 antibody [EPR2673] - Oligodendrocyte Marker

BOND RX™ Validated|20ul selling size|Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Olig2 antibody [EPR2673] - Oligodendrocyte Marker (AB109186)

  • 5
  • 22
Primary Antibodies

AB6319

Anti-CNPase antibody [11-5B]

BOND RX™ Validated|KO Validated

Western blot - Anti-CNPase antibody [11-5B] (AB6319)

  • 5
  • 39
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GPR123 also known as Probable G-protein coupled receptor 123 is a member of the adhesion GPCR family. This receptor has a molecular mass of approximately 85 kDa. GPR123 primarily expresses in the central nervous system including regions like the brain and spinal cord. Researchers have identified GPR123's structure as containing several conserved domains common to the GPCR superfamily which play an important role in signal transduction across cell membranes.
Biological function summary

Adhesion GPCRs like GPR123 participate in various cellular processes often interacting with extracellular matrix components. GPR123 does not act in isolation but forms part of larger protein complexes essential for cell signaling. In neural tissues GPR123 is involved in processes related to cell adhesion migration and possibly axon guidance. Understanding its interactions can help illuminate its contribution to neural development and function.

Pathways

GPR123 likely integrates into the Wnt and MAPK signaling pathways which are critical for numerous cellular functions including proliferation and differentiation. Within these pathways GPR123 might work in conjunction with proteins like beta-catenin and MAPK kinases to modulate downstream effects. These pathways are significant in neural tissues suggesting GPR123's role in neural activity and development.

The specific functions of GPR123 link to neurological conditions such as epilepsy and schizophrenia. Dysfunction in GPR123-mediated signaling might lead to aberrant neural development or activity contributing to these disorders. In the case of epilepsy proteins related to GPR123 in pathways like the Wnt cascade including APC and Axin might also interact during disease pathology. For schizophrenia disruptions in pathways where GPR123 intersects could influence gene regulation and synaptic plasticity connecting it to proteins involved in neurotransmission.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Orphan receptor.
See full target information ADGRA1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Genes & genomics 43:1317-1325 PubMed33945147

2021

Adhesion GPR123 is an indicator for recurrence and prognosis in bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yaming Liu,Guodong Wang,Tongwei Cui,Lin Lv
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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