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AB236970

Anti-GPR176 antibody

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Rabbit Polyclonal GPR176 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GPR176 aa 300-550.

대체 명칭 보기

G-protein coupled receptor 176, HB-954, GPR176

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-GPR176 antibody (AB236970)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GPR176 antibody (AB236970)

A431 (human epidermoid carcinoma cell line) cells stained for GPR176 (green) using ab236970 at 1/50 dilution in ICC/IF, followed by Alexa Fluor 488-congugated Goat Anti-Rabbit IgG (H+L) secondary antibody.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human GPR176 aa 300-550. The exact immunogen used to generate this antibody is proprietary information.

Q14439

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대체품

Primary Antibodies

AB122605

Anti-GPR176 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR176 antibody (AB122605)

  • 0
  • 0
Primary Antibodies

AB184558

Anti-GPR176 antibody [EPR13983] - N-terminal

RabMAb|Recombinant

Western blot - Anti-GPR176 antibody [EPR13983] - N-terminal (AB184558)

  • 0
  • 0

보완 제품

Assay Kits

AB83366

Iron Assay Kit (Colorimetric)

Biochemical assay - Iron Assay Kit (Colorimetric) (AB83366)

  • 4
  • 3
Assay Kits

AB118970

Lipid Peroxidation (MDA) Assay Kit (Colorimetric/Fluorometric)

Biochemical assay - Lipid Peroxidation (MDA) Assay Kit (Colorimetric/Fluorometric) (AB118970)

  • 5
  • 3
Primary Antibodies

AB213480

Anti-PD-L1 antibody [EPR20529]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-PD-L1 antibody [EPR20529] (AB213480)

  • 5
  • 5
Assay Kits

AB138881

GSH/GSSG Ratio Detection Assay Kit (Fluorometric - Green)

Functional Studies - GSH/GSSG Ratio Detection Assay Kit (Fluorometric - Green) (AB138881)

  • 4
  • 5
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GPR176 also known as G protein-coupled receptor 176 is a member of the G protein-coupled receptor family. The receptor has a molecular mass of around 47 kDa. Usually you find it expressed in various tissues including the brain and lymphoid organs. As a GPCR GPR176 may act through activating specific G proteins that transmit signals inside cells leading to various cellular responses.
Biological function summary

GPR176 shows roles in regulating circadian rhythms and immune system functions. It appears not to form a complex but influences biological processes through its signaling pathways. Evidence suggests that it modulates certain aspects of the immune response by impacting the behavior of immune cells.

Pathways

GPR176 participates in pathways connected to the regulation of circadian rhythms and immune system signaling. It interacts with pathways involving other GPCRs which are critical for maintaining physiological homeostasis. Proteins such as CLOCK and PER1 in the circadian rhythm pathway are related to the actions of GPR176 helping coordinate daily physiological cycles.

Researchers link GPR176 to conditions like immune dysfunction and mood disorders. In particular dysregulation of circadian rhythms can have ties with mood disorders where GPR176 plays a role. The target also shows relevance to immune-related conditions interconnected with proteins like NF-kB which influence inflammation and immune responses.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production.
See full target information GPR176
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Communications biology 5:780 PubMed35918402

2022

Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth.

Applications

Unspecified application

Species

Unspecified reactive species

Rossella Delle Donne,Rosa Iannucci,Laura Rinaldi,Luca Roberto,Maria A Oliva,Emanuela Senatore,Domenica Borzacchiello,Luca Lignitto,Giorgio Giurato,Francesca Rizzo,Assunta Sellitto,Francesco Chiuso,Salvatore Castaldo,Giovanni Scala,Virginia Campani,Valeria Nele,Giuseppe De Rosa,Chiara D'Ambrosio,Corrado Garbi,Andrea Scaloni,Alessandro Weisz,Concetta Ambrosino,Antonella Arcella,Antonio Feliciello
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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