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AB230025

Anti-GPX5 antibody

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(1 출판물)

Rabbit Polyclonal GPX5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Epididymal secretory glutathione peroxidase aa 1-100.

대체 명칭 보기

Epididymal secretory glutathione peroxidase, Epididymis-specific glutathione peroxidase-like protein, Glutathione peroxidase 5, EGLP, GPx-5, GSHPx-5, GPX5

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPX5 antibody (AB230025)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPX5 antibody (AB230025)

Paraffin-embedded human liver tissue stained for GPX5 with ab230025 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Epididymal secretory glutathione peroxidase aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O75715

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보완 제품

Primary Antibodies

AB317744

Anti-GPX8 antibody [EPR28823-80]

20ul selling size|Recombinant|RabMAb|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-GPX8 antibody [EPR28823-80] (AB317744)

  • 0
  • 0
Primary Antibodies

AB137431

Anti-Glutathione Peroxidase 2/GPX2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutathione Peroxidase 2/GPX2 antibody (AB137431)

  • 0
  • 0
Primary Antibodies

AB256470

Anti-Glutathione Peroxidase 3/GPx-3 antibody [EPR22815-112]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Anti-Glutathione Peroxidase 3/GPx-3 antibody [EPR22815-112] (AB256470)

  • 0
  • 1
Primary Antibodies

AB228941

Anti-GPx-7 antibody

Western blot - Anti-GPx-7 antibody (AB228941)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GPX5 also known as Glutathione Peroxidase 5 or Epididymal Secretory Glutathione Peroxidase is an antioxidant enzyme that reduces hydrogen peroxide and lipid peroxides. It belongs to the glutathione peroxidase family and has a mass of approximately 22 kDa. GPX5 is expressed mainly in the epididymis of the male reproductive tract. It plays an important role in protecting sperm from oxidative stress by neutralizing harmful peroxides which can damage cellular structures and affect sperm functionality.
Biological function summary

GPX5 functions to preserve the integrity of sperm cells during their maturation. By reducing oxidative stress it safeguards the membrane lipid components and essential proteins from oxidative damage. GPX5 operates independently and does not require selenium as a cofactor which differentiates it from other family members. This unique characteristic allows it to function in environments that may have varying selenium levels providing an essential antioxidant defense in sperm-rich regions.

Pathways

GPX5 integrates into cellular antioxidant mechanisms and is involved in the reduction-oxidation (redox) homeostasis. It participates in the detoxification of peroxides alongside proteins such as catalase and other glutathione peroxidases including GPX1. The pathway interaction establishes a balance between oxidants and antioxidants maintaining cellular health and efficiency in detoxifying reactive oxygen species.

GPX5 potentially associates with male infertility due to its role in safeguarding sperm from oxidative damage. Lower activity or expression levels of GPX5 may contribute to increased oxidative stress in spermatozoa leading to impaired sperm function and reduced fertility. Additionally oxidative stress-related conditions could be linked to other proteins such as superoxide dismutases which like GPX5 play roles in reducing reactive oxygen species within reproductive tissues.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
See full target information Epididymal secretory glutathione peroxidase
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death & disease 12:42 PubMed33414446

2021

TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Susu Guo,Yuxin Chen,Yueyue Yang,Xiao Zhang,Lifang Ma,Xiangfei Xue,Yongxia Qiao,Jiayi Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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