Rabbit Polyclonal Granuphilin antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SYTL4 aa 150-350.
대체 명칭 보기
Synaptotagmin-like protein 4, Exophilin-2, Granuphilin, SYTL4
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-Granuphilin antibody (AB224047)
PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for Granuphilin (green) using ab224047 at 4 μg/ml in ICC/IF.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Granuphilin antibody (AB224047)
Paraffin-embedded human pancreas tissue stained for Granuphilin using ab224047 at 1/200 dilution in immunohistochemical analysis.
Reactivity 정보
특성 및 보관 정보
제형
Purification 테크닉
보관 버퍼
배송 시 보관 조건
적절한 단기 보관 기간
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Granuphilin impacts insulin secretion by managing the docking of insulin granules. It is an essential regulator within the secretory pathway. Granuphilin does not work alone but instead associates with a complex of proteins including Rab27A to facilitate precise targeting and fusion of vesicles with cell membranes. This interaction impacts the exocytosis process vital for hormone release.
Pathways
Granuphilin integrates into the insulin secretion pathway and the exocytosis pathway. It acts alongside proteins such as Rab3 influencing the regulation of granule docking and secretion from pancreatic beta cells. By regulating these pathways granuphilin plays a role in glucose homeostasis and helps maintain metabolic balance within the body.
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타겟 정보
제품이 사용된 논문 (2)
Recent publications for all applications. Explore the 전체 목록 and refine your search
Cell death & disease 12:877 PubMed34564708
2021
Applications
Unspecified application
Species
Unspecified reactive species
Nature communications 12:3970 PubMed34172739
2021
Applications
Unspecified application
Species
Unspecified reactive species
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