JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB216953

Anti-GRINA antibody

Be the first to review this product! 리뷰 제출

|

(3 제품이 사용된 논문 )

Rabbit Polyclonal GRINA antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 3 publications.

대체 명칭 보기

Glutamate [NMDA] receptor associated protein 1, Glutamate receptor, NMDA subtype, glutamate binding subunit, Glutamate receptor, ionotropic, N methyl D aspartate associated protein 1 (glutamate binding), HNRGW, MGC99687, NMDA receptor glutamate binding subunit, NMDARA1, Putative MAPK activating protein PM02, TMBIM3, Transmembrane BAX inhibitor motif containing 3

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRINA antibody (AB216953)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRINA antibody (AB216953)

Immunohistochemical analysis of Paraformaldehyde-fixed, paraffin-embedded rat testis tissue labeling GRINA with ab216953 at a 1/200 dilution, followed by a conjugated secondary and DAB staining.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P

applications

style
left-column

보완 제품

Reagents, Controls & Accessories

AB176753

Phalloidin-iFluor 488 Reagent

Immunocytochemistry/ Immunofluorescence - Phalloidin-iFluor 488 Reagent (AB176753)

  • 5
  • 14
Primary Antibodies

AB205

Anti-F-actin antibody [NH3]

Immunocytochemistry/ Immunofluorescence - Anti-F-actin antibody [NH3] (AB205)

  • 4
  • 11
Biochemicals

AB285390

DAPI

  • 0
  • 0
Biochemicals

AB145597

Bisbenzimide H 33342 (Hoechst 33342), adenine-thymine selective DNA fluorescent stain

Chemical Structure - Bisbenzimide H 33342 (Hoechst 33342), adenine-thymine selective DNA fluorescent stain (AB145597)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GRINA also known as Glutamate Receptor Ionotropic NMDA Associated Protein 5 or NMDAR Subunit 5 is a protein encoded by the GRINA gene. It is a transmembrane protein involved in the regulation of ion channels specifically interacting with the NMDA receptor complexes. GRINA weighs approximately 50 kDa and is expressed predominantly in the central nervous system notably in the cerebral cortex and hippocampus. Its presence in these regions indicates its role in neuronal communication and signaling.
Biological function summary

The GRINA protein modulates calcium ion flux in neurons influencing neuronal excitability and synaptic plasticity. This role makes it an important component in maintaining normal neurotransmission. GRINA associates with NMDA receptor complexes which consist of several other subunits. This association governs the receptor's function in synaptic signaling and plasticity affecting learning and memory processes.

Pathways

GRINA participates in the glutamatergic synapse and calcium signaling pathways. In these pathways GRINA works alongside the protein GRIN1 a critical subunit of the NMDA receptor complex to facilitate ion flow and synaptic transmission. This involvement situates GRINA as an important regulatory factor in neuronal activity and signal propagation within the brain.

GRINA has links to neurodegenerative diseases and psychiatric disorders including Alzheimer’s disease and schizophrenia. Its association with the NMDA receptor complex implies its contribution to the pathophysiology of these conditions. For example alterations in GRINA function can affect GRIN2B another NMDA receptor subunit implicated in neuropsychiatric diseases further connecting GRINA to these disorders. Understanding GRINA's interactions and functions can offer insights into therapeutic targets for these diseases.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

See full target information GRINA
style
left-column

제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Bioengineered 13:4844-4856 PubMed35152833

2022

Human umbilical cord mesenchymal stem cells contribute to the reconstruction of bladder function after acute spinal cord injury via p38 mitogen-activated protein kinase/nuclear factor-kappa B pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jue Li,Jiliang Huang,Ling Chen,Wei Ren,Wenzhi Cai

Molecular medicine reports 24: PubMed34368871

2021

Glutamate receptor, ionotropic, N‑methyl D‑aspartate‑associated protein 1 promotes colorectal cancer cell proliferation and metastasis, and is negatively regulated by miR‑296‑3p.

Applications

Unspecified application

Species

Unspecified reactive species

Zaihua Yan,Peidong Li,Yuan Xue,Hongpeng Tian,Tong Zhou,Guangjun Zhang

Protein & cell 12:545-556 PubMed33548033

2021

Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Dandan Liang,Zhigang Xue,Jinfeng Xue,Duanyang Xie,Ke Xiong,Huixing Zhou,Fulei Zhang,Xuling Su,Guanghua Wang,Qicheng Zou,Yi Liu,Jian Yang,Honghui Ma,Luying Peng,Chunyu Zeng,Gang Li,Li Wang,Yi-Han Chen
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com