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AB122514

Anti-GRIP1 antibody

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(1 출판물)

Rabbit Polyclonal GRIP1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GRIP1 aa 800 to C-terminus.
1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRIP1 antibody (AB122514)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRIP1 antibody (AB122514)

ab122514 at 1/75 dilution staining GRIP1 in Paraffin-embedded Human Pancreas tissue by Immunohistochemistry.
Note : strong cytoplasmic positivity in exocrine pancreas.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human GRIP1 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y3R0

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대체품

Primary Antibodies

AB226201

Anti-GRIP1 antibody

Immunoprecipitation - Anti-GRIP1 antibody (AB226201)

  • 0
  • 0

보완 제품

Primary Antibodies

AB140863

Anti-MRGX3 antibody - Extracellular domain

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (AB140863)

  • 0
  • 0
Primary Antibodies

AB290727

Anti-PICK1 antibody [EPR25155-48]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-PICK1 antibody [EPR25155-48] (AB290727)

  • 0
  • 0
Primary Antibodies

AB249660

Anti-GRASP1 antibody [EPR11703] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-GRASP1 antibody [EPR11703] - BSA and Azide free (AB249660)

  • 0
  • 0
Primary Antibodies

AB140486

Anti-5HT1D Receptor antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT1D Receptor antibody (AB140486)

  • 1
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p>Use buffer at pH 6 for antigen retrieval.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GRIP1 also known as Glutamate Receptor Interacting Protein 1 is a protein that serves as a scaffold for various cellular signaling molecules. It weighs approximately 127 kDa. GRIP1 is expressed mainly in the central nervous system where it interacts with membrane proteins to facilitate their proper localization and function. It supports the clustering and stabilization of AMPA receptors at synaptic sites which is essential for synaptic transmission and plasticity.
Biological function summary

GRIP1 plays a role in synaptic formation and maintenance. It is a part of a multi-protein complex that influences the trafficking and stabilization of AMPA-type glutamate receptors. By regulating these receptors it contributes to synaptic plasticity a process fundamental for learning and memory. Additionally GRIP1 interacts with proteins like GRASP and liprin-α which further regulate synaptic density and neural connectivity.

Pathways

GRIP1 is involved in synaptic signaling pathways and neuronal communication. It participates in the maintenance of long-term potentiation (LTP) an activity-dependent strengthening of synapses that is central to memory and learning. GRIP1 interacts closely with proteins like GRASP1 and PICK1 in these pathways. These interactions are critical for mediating changes in synaptic strength and receptor turnover that underpin neural plasticity.

GRIP1's dysregulation associates with neuropsychiatric conditions such as autism spectrum disorder (ASD) and schizophrenia. Alterations in GRIP1 function can affect AMPA receptor trafficking impacting synaptic efficiency and cognitive function. In ASD GRIP1 connects with the protein SHANK3 influencing synapse functionality and neuronal development. In schizophrenia irregularities in GRIP1 contribute to synaptic dysfunction linking it to a broader network of proteins impacting glutamate signaling.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed : 10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
See full target information GRIP1

대체 명칭 보기

Glutamate receptor-interacting protein 1, GRIP-1, GRIP1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록and refine your search

PloS one 10:e0117581 PubMed25807145

2015

Discovery of molecular markers to discriminate corneal endothelial cells in the human body.

Applications

Unspecified application

Species

Unspecified reactive species

Masahito Yoshihara,Hiroko Ohmiya,Susumu Hara,Satoshi Kawasaki,Yoshihide Hayashizaki,Masayoshi Itoh,Hideya Kawaji,Motokazu Tsujikawa,Kohji Nishida
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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