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AB64805

Anti-GTF2IRD1 antibody

3

(2 리뷰들)

|

(1 출판물)

Rabbit Polyclonal GTF2IRD1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GTF2IRD1.
1 이미지
Western blot - Anti-GTF2IRD1 antibody (AB64805)
  • WB

Unknown

Western blot - Anti-GTF2IRD1 antibody (AB64805)

All lanes:

Western blot - Anti-GTF2IRD1 antibody (ab64805) at 1/500 dilution

Lane 1:

Extracts from 293 cells, no peptide at 5 µg

Lane 2:

Extracts from 293 cells, plus peptide at 5 µg

Predicted band size: 106 kDa

Observed band size: 106 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human GTF2IRD1. The exact immunogen used to generate this antibody is proprietary information.

Q9UHL9

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보완 제품

Primary Antibodies

AB109028

Anti-HP1 alpha antibody [EPR5777] - Heterochromatin marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HP1 alpha antibody [EPR5777] - Heterochromatin marker (AB109028)

  • 5
  • 9
Primary Antibodies

AB240190

Anti-KDEL antibody [EPR12668] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-KDEL antibody [EPR12668] - BSA and Azide free (AB240190)

  • 0
  • 0
Primary Antibodies

AB280354

Anti-DDR2 antibody [EPR18826-119]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-DDR2 antibody [EPR18826-119] (AB280354)

  • 0
  • 0
Primary Antibodies

AB235305

Anti-CBX2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CBX2 antibody (AB235305)

  • 3
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GTF2IRD1 also known as General Transcription Factor II-I repeat domain-containing protein 1 is a transcription factor involved in gene regulation. It has a molecular mass of around 122 kDa. The protein expresses widely in several tissues including the brain heart and skeletal muscle. GTF2IRD1 directly interacts with DNA to modulate transcriptional activity acting as an important regulator in the control of gene expression by binding to specific target sequences.
Biological function summary

GTF2IRD1 influences cellular development and differentiation. It is found as part of a larger transcriptional complex essential for its function in regulating genes involved in neural development and craniofacial structure. By influencing these developmental processes GTF2IRD1 helps in maintaining structural integrity and functional capabilities of cells particularly in the nervous system.

Pathways

GTF2IRD1 connects with multiple molecular pathways including the MAPK signaling pathway where it influences various downstream effects important for cellular responses. It also interacts with components like MAPK1 and other related proteins further integrating into the transcriptional regulatory network. The modulation of these signaling cascades highlights GTF2IRD1's important role in cellular signaling and response.

Abnormal expression or mutations in GTF2IRD1 associate with Williams-Beuren syndrome a developmental disorder characterized by growth delays and cardiovascular problems. Its interactions with proteins like ELN (elastin) and LIMK1 in the genetic region affected by the syndrome suggest a mechanism for the diverse symptoms. Further understanding of GTF2IRD1 interactions presents potential opportunities for targeted therapeutic interventions in related disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity).
See full target information GTF2IRD1

대체 명칭 보기

CREAM1, GTF3, MUSTRD1, RBAP2, WBSCR11, WBSCR12, GTF2IRD1, General transcription factor II-I repeat domain-containing protein 1, GTF2I repeat domain-containing protein 1, General transcription factor III, MusTRD1/BEN, Muscle TFII-I repeat domain-containing protein 1, Slow-muscle-fiber enhancer-binding protein, USE B1-binding protein, Williams-Beuren syndrome chromosomal region 11 protein, Williams-Beuren syndrome chromosomal region 12 protein
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:15356-68 PubMed25392503

2014

The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina.

Applications

IHC, WB, IP

Species

Mouse, Mouse, Mouse

Tomohiro Masuda,Xiaodong Zhang,Cindy Berlinicke,Jun Wan,Anitha Yerrabelli,Elizabeth A Conner,Sten Kjellstrom,Ronald Bush,Snorri S Thorgeirsson,Anand Swaroop,Shiming Chen,Donald J Zack
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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