JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB36905

Anti-H Cadherin antibody

4

(3 리뷰들)

|

(4 제품이 사용된 논문 )

Rabbit Polyclonal H Cadherin antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CDH13 aa 150-200.
2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H Cadherin antibody (AB36905)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H Cadherin antibody (AB36905)

Immunohistochemistry (Formalin-fixed paraffin embedded sections) of mouse brain tissue labeling H Cadherin with Anti-H Cadherin antibody (ab36905) at 5μg/ml.

Western blot - Anti-H Cadherin antibody (AB36905)
  • WB

Supplier Data

Western blot - Anti-H Cadherin antibody (AB36905)

Lane 1:

Western blot - Anti-H Cadherin antibody (ab36905) at 0.5 µg/mL

Lane 2:

Western blot - Anti-H Cadherin antibody (ab36905) at 1 µg/mL

All lanes:

3T3 cell lysate.

Predicted band size: 78 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human CDH13 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

P55290

Specificity

This antibody is specific for H Cadherin.

style
left-column

대체품

Primary Antibodies

AB167407

Anti-H Cadherin antibody [EPR9621]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H Cadherin antibody [EPR9621] (AB167407)

  • 5
  • 2

보완 제품

Assay Kits

AB309455

Human Cadherin 13 ELISA

Sandwich ELISA - Human Cadherin 13 ELISA (AB309455)

  • 0
  • 0
Primary Antibodies

AB32072

Anti-c-Myc antibody [Y69] - ChIP Grade

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [Y69] - ChIP Grade (AB32072)

  • 4
  • 56
Primary Antibodies

AB32047

Anti-AMPK alpha 1 antibody [Y365]

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Western blot - Anti-AMPK alpha 1 antibody [Y365] (AB32047)

  • 5
  • 6
Primary Antibodies

AB52946

Anti-Histone H3 (acetyl K14) antibody [EP964Y] - ChIP Grade

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Histone H3 (acetyl K14) antibody [EP964Y] - ChIP Grade (AB52946)

  • 5
  • 12
Primary Antibodies

AB52894

Anti-EGFR antibody [EP38Y]

BOND RX™ Validated|KO Validated|RabMAb|Lab Essentials|20ul selling size|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFR antibody [EP38Y] (AB52894)

  • 5
  • 24
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

H Cadherin also known as Cadherin-13 or T-cadherin is a unique member of the cadherin family of cell adhesion molecules. It weighs approximately 95 kDa. Unlike classical cadherins H Cadherin lacks the transmembrane and cytoplasmic domains anchoring instead to the membrane via a glycosylphosphatidylinositol (GPI) anchor. H Cadherin expresses in various tissues including endothelial cells cardiac muscle and neurons suggesting its versatile role in different biological contexts.
Biological function summary

The protein plays a role in cell-cell interactions and tissue organization without forming typical adherens junctions. Researchers have identified H Cadherin as a part of the significant complex involved in neural network formation vascular patterning and cardiac tissue integrity. In neurons its expression modulates axon growth and guidance. In the cardiovascular system it contributes to heart function and blood vessel maintenance through its adhesive properties and involvement in signaling pathways.

Pathways

Several biological networks incorporate H Cadherin as an important element. Notably it participates in the Wnt signaling and PI3K/AKT pathways. H Cadherin interacts with proteins such as β-catenin in the Wnt pathway influencing cellular responses like proliferation and differentiation. In the PI3K/AKT pathway the protein may affect cell survival and metabolism. These interactions illustrate H Cadherin's involvement in important cellular processes.

H Cadherin has significant associations with cardiovascular diseases and certain cancers. Altered expression levels or mutations in H Cadherin can disrupt cellular adhesion and signaling contributing to the progression of atherosclerosis and tumor formation. In cancer linkages between H Cadherin and other cadherin family members like E-cadherin suggest complex interactions that can modulate tumor cell behavior influencing invasion and metastasis.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
See full target information CDH13

대체 명칭 보기

CDHH, CDH13, Cadherin-13, Heart cadherin, P105, Truncated cadherin, H-cadherin, T-cad, T-cadherin
style
left-column

제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancers 16: PubMed38791932

2024

The Role of T-Cadherin (CDH13) in Treatment Options with Garcinol in Melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Sebastian Staebler,Sebastian Hoechst,Aranya Thongmao,Nadja Schneider,Anja-Katrin Bosserhoff,Silke Kuphal

Journal of oncology 2020:7262479 PubMed32411241

2020

AdipoRon Affects Cell Cycle Progression and Inhibits Proliferation in Human Osteosarcoma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Luigi Sapio,Ersilia Nigro,Angela Ragone,Alessia Salzillo,Michela Illiano,Annamaria Spina,Rita Polito,Aurora Daniele,Silvio Naviglio

Cell biochemistry and biophysics 70:491-7 PubMed24888493

2014

Down-regulation of adiponectin receptors in osteoarthritic chondrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Wang,Jun Cai,Jingcheng Wang,Chuanzhi Xiong,Lianqi Yan,Zhiqiang Zhang,Yongchao Fang,Jianning Zhao

Pigment cell & melanoma research 22:296-306 PubMed19368692

2009

H-cadherin expression reduces invasion of malignant melanoma.

Applications

WB, ICC/IF

Species

Human, Human

Silke Kuphal,Adam C Martyn,Julie Pedley,Lisa M Crowther,Vanessa F Bonazzi,Peter G Parsons,Anja K Bosserhoff,Nicholas K Hayward,Glen M Boyle
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com