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AB188978

Anti-H4R antibody

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Rabbit Polyclonal H4R antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HRH4.

대체 명칭 보기

GPCR105, HRH4, Histamine H4 receptor, H4R, HH4R, AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H4R antibody (AB188978)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H4R antibody (AB188978)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Human lymph node tissue labeling H4R with ab188978 at 24 μg/ml.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human HRH4. The exact immunogen used to generate this antibody is proprietary information.

Q9H3N8

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

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보완 제품

Primary Antibodies

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Anti-NK-1R antibody [EPR28834-27] - BSA and Azide free

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NK-1R antibody [EPR28834-27] - BSA and Azide free (AB317505)

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Primary Antibodies

AB211017

Anti-Indoleamine 2, 3-dioxygenase antibody [EPR20374]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Indoleamine 2, 3-dioxygenase antibody [EPR20374] (AB211017)

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Primary Antibodies

AB237047

Anti-GPCR MRGX2 antibody

Western blot - Anti-GPCR MRGX2 antibody (AB237047)

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Primary Antibodies

AB315104

Anti-Periostin antibody [RM1074]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody [RM1074] (AB315104)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "12-24 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The histamine H4 receptor (H4R) functions mechanically as a G protein-coupled receptor (GPCR). It binds to histamine a regulatory biogenic amine involved in immune response. Its molecular mass is approximately 44 kDa. H4R exhibits expression mainly in bone marrow thymus spleen and other immune-related tissues. Researchers sometimes refer to it as HH4R.
Biological function summary

The H4 receptor plays a significant role in the regulation of immune cell chemotaxis and cytokine release following histamine activation. It does not form part of a larger receptor complex yet it is instrumental in immune system modulation. Its activity affects the migration of eosinophils and mast cells influencing inflammatory responses.

Pathways

The histamine H4 receptor is highly involved in the histamine signaling pathway and the immune response pathway. These pathways modulate various physiological functions and responses to allergens. Within these pathways H4R interacts with proteins such as the histamine H1 and H2 receptors which also mediate histamine-related responses across different tissues.

The H4 receptor has connections to conditions like allergic rhinitis and asthma. Its role in immune cell recruitment and activation intimates a link to these inflammatory disorders. In these conditions H4R works alongside histamine H1 receptor both contributing to the severity and progression of allergic responses. Researchers explore the receptor as a potential therapeutic target for these diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses (PubMed : 26948974). Mediates chemotaxis of immune cells to sites of inflammation or injury by responding to histamine (PubMed : 26948974). Activation by histamine also influences the release of proinflammatory cytokines such as TNF, CCL4, IL6 and IFN-gamma (PubMed : 29600327, PubMed : 31583075). Ligand binding induces a conformation change that triggers signaling via G(i)/GNAI1 leading to decreased intracellular cAMP levels by inhibiting adenylate cyclase activity (PubMed : 39333117). In addition, plays a role in the control of renal reabsorption processes, particularly albumin uptake (By similarity).
See full target information HRH4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Mucosal immunology 11:861-870 PubMed29363669

2018

Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis.

Applications

Unspecified application

Species

Unspecified reactive species

J B Wechsler,A Szabo,C L Hsu,R A Krier-Burris,H A Schroeder,M Y Wang,R G Carter,T E Velez,L M Aguiniga,J B Brown,M L Miller,B K Wershil,T A Barrett,P J Bryce
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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