Anti-Hairy antibody [1/24]

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This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Hairy helps regulate the timing of development processes in embryogenesis. It acts as a transcriptional repressor and is part of the Hes family proteins often forming a complex with other bHLH proteins. Through its repressive actions Hairy controls cell fate decisions and maintains the balance between proliferation and differentiation in developing tissues. It regulates gene expression patterns that are essential for precise body plan formation during embryonic development.

Pathways

Hairy is intimately connected through the Notch signaling pathway which is critical for cell fate determination and pattern formation in multicellular organisms. The interaction with Notch signaling components like the Notch receptor and its ligands influences cellular communication necessary for tissue organization. Additionally Hairy is involved in the segmentation clock pathway interacting with proteins such as the Drosophila homolog of the mammalian Hes1 and Hes5 to coordinate segmentation during development.