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AB34763

Anti-Hantavirus glycoprotein G2 antibody [10B8]

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(2 제품이 사용된 논문 )

Mouse Monoclonal Glycoprotein N antibody. Suitable for I-ELISA, WB and reacts with Hantavirus Puumala strain, Recombinant full length protein - Hantavirus Puumala strain samples. Cited in 2 publications.

관련 conjugated 항체와 다양한 조성의 항체 (2)

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

10B8

Isotype

IgG1

Carrier free

No

Reacts with

Hantavirus Puumala strain

Applications

I-ELISA, WB

applications

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보완 제품

Primary Antibodies

AB271180

Rabbit monoclonal [EPR24334-118] to SARS-CoV-2 nucleocapsid protein

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Rabbit monoclonal [EPR24334-118] to SARS-CoV-2 nucleocapsid protein (AB271180)

  • 5
  • 4
Proteins & Peptides

AB273530

Recombinant Human coronavirus SARS-CoV-2 nucleocapsid protein (His tag)

ELISA - Recombinant Human coronavirus SARS-CoV-2 nucleocapsid protein (His tag) (AB273530)

  • 0
  • 0
Reagents, Controls & Accessories

AB176753

Phalloidin-iFluor 488 Reagent

Immunocytochemistry/ Immunofluorescence - Phalloidin-iFluor 488 Reagent (AB176753)

  • 5
  • 14
Proteins & Peptides

AB74555

Recombinant Hantavirus Puumala, strain Vranica, nucleocapsid protein

SDS-PAGE - Recombinant Hantavirus Puumala, strain Vranica, nucleocapsid protein (AB74555)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IELISA" : {"fullname" : "Indirect ELISA", "shortname":"I-ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hantavirus Puumala strain": { "IELISA-species-checked": "guaranteed", "IELISA-species-dilution-info": "1/1000 - 1/10000", "IELISA-species-notes": "<p></p>", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant full length protein - Hantavirus Puumala strain": { "IELISA-species-checked": "notRecommended", "IELISA-species-dilution-info": "", "IELISA-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }
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제품 세부 정보

This product was changed from ascites to tissue culture supernatant on 28/11/2017. Please note that the dilutions may need to be adjusted accordingly.
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.2 - 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Hantavirus glycoprotein G2 sometimes referred to simply as G2 is an integral membrane protein that plays a critical role in the virus's life cycle. Mechanically G2 facilitates viral entry into host cells by mediating the fusion of the viral envelope with the host cell membrane. This protein is expressed on the surface of the hantavirus envelope and together with glycoprotein G1 forms the glycoprotein complex essential for viral infectivity. The exact molecular mass of the G2 protein can vary between hantavirus strains but typically ranges around 30 kilodaltons.
Biological function summary

The G2 protein plays a pivotal role in the host-pathogen interaction mediating the initial binding and entry process of the virus into host cells. On the surface of the virus the glycoprotein complex consisting of G1 and G2 binds to cellular receptors triggering endocytosis and facilitating the release of viral RNA into the cytoplasm. This complex assembly accounts for the efficient recognition and invasion of permissive cells enabling the virus to hijack host machinery for replication.

Pathways

Hantavirus glycoprotein G2's function integrates into the endocytosis and viral replication pathways. The glycoprotein machinery cooperates with cellular proteins to accomplish membrane fusion and viral internalization. Acidification within endocytic vesicles modulates the conformational change of G2 for membrane fusion linking it indirectly to proteins involved in cellular trafficking such as clathrin and dynamin. These interactions are important for the cytoplasmic release of viral components and subsequent viral propagation.

Hantavirus glycoprotein G2 is closely associated with the pathogenesis of hantavirus infections including hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The interaction between the G2 protein and host endothelial cells is an important factor in the vascular permeability and endothelial dysfunction observed in these diseases. While G2 interacts directly with the host receptors in the context of these disorders it functions alongside cellular proteins that may impact vascular integrity and immune responses such as integrins and VEGF receptors contributing to the disease's clinical manifestations.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information Hantavirus glycoprotein G2
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

PLoS pathogens 16:e1008297 PubMed32032391

2020

Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2.

Applications

Unspecified application

Species

Unspecified reactive species

Carles Solà-Riera,Marina García,Hans-Gustaf Ljunggren,Jonas Klingström

Viruses 6:640-60 PubMed24513568

2014

The use of chimeric virus-like particles harbouring a segment of hantavirus Gc glycoprotein to generate a broadly-reactive hantavirus-specific monoclonal antibody.

Applications

WB

Species

Human

Aurelija Zvirbliene,Indre Kucinskaite-Kodze,Ausra Razanskiene,Rasa Petraityte-Burneikiene,Boris Klempa,Rainer G Ulrich,Alma Gedvilaite
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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