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AB243102

Anti-Heat-labile enterotoxin B chain antibody

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Rabbit Polyclonal Heat-labile enterotoxin B chain antibody. Suitable for ELISA, Dot, WB and reacts with Clostridium perfringens, Purified native protein - Clostridium perfringens samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Clostridium perfringens Heat-labile enterotoxin B chain.

대체 명칭 보기

Heat-labile enterotoxin B chain, cpe

2 이미지
Western blot - Anti-Heat-labile enterotoxin B chain antibody (AB243102)
  • WB

Supplier Data

Western blot - Anti-Heat-labile enterotoxin B chain antibody (AB243102)

All lanes:

Anti-MFF antibody (<a href='/ko/products/unavailable/mff-antibody-ab242102'>ab242102</a>) at 1 µg/mL

All lanes:

Crude extract of Clostridium perfringens

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/ko/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Predicted band size: 35 kDa

false

Dot Blot - Anti-Heat-labile enterotoxin B chain antibody (AB243102)
  • Dot

Supplier Data

Dot Blot - Anti-Heat-labile enterotoxin B chain antibody (AB243102)

Dot blot of highly purified C.perfringence enterotoxin (antigen) using ab243102 at the indicated concentrations. ab97051 was used as the secondary antibody at 1/20,000 dilution for 60 minutes.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Clostridium perfringens

Applications

WB, ELISA, Dot

applications

Immunogen

Native Full Length Protein corresponding to Clostridium perfringens Heat-labile enterotoxin B chain.

P01558

Specificity

Clostridium perfringens enterotoxin.(food-poisoning strains).

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보완 제품

Primary Antibodies

AB82592

Anti-groEL antibody [9A1/2]

Western blot - Anti-groEL antibody [9A1/2] (AB82592)

  • 0
  • 0
Primary Antibodies

AB35132

Anti-Listeria monocytogenes antibody

  • 5
  • 1
Primary Antibodies

AB35156

Anti-Salmonella antibody

  • 0
  • 0
Primary Antibodies

AB8274

Anti-Salmonella typhimurium LPS antibody [1E6]

Western blot - Anti-Salmonella typhimurium LPS antibody [1E6] (AB8274)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "Dot" : {"fullname" : "Dot Blot", "shortname":"Dot"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Clostridium perfringens": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "Dot-species-checked": "guaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Purified native protein - Clostridium perfringens": { "ELISA-species-checked": "notRecommended", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "Dot-species-checked": "testedAndGuaranteed", "Dot-species-dilution-info": "1/100000 - 1/200000", "Dot-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 6.5 - 8.5 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Heat-labile enterotoxin B chain (LT-B) also known as Escherichia coli heat-labile enterotoxin subunit B plays an important role in the functioning of certain bacterial toxins. LT-B with a mass of approximately 11.6 kDa forms a pentameric structure. It expresses in specific strains of Escherichia coli often within the gastrointestinal tract. The B chain helps the toxin bind to host cells by interacting with the GM1 ganglioside receptors on the surface of epithelial cells facilitating the entry of the catalytic A subunit into the cell.
Biological function summary

LT-B acts as a non-toxic subunit that enables the binding of the toxin complex to target cells. It forms a pentamer a stable ring structure which contributes to the adherence of bacteria to intestinal mucosa. While LT-B itself is not toxic it is essential for the delivery of the toxic A chain which exerts the physiological effects of the toxin. The entire enterotoxin complex plays a part in increasing intestinal secretion resulting in symptoms such as diarrhea.

Pathways

LT-B facilitates the activation of signaling events in the host cell that lead to increased cyclic AMP levels via the adenylate cyclase pathway. This activation disrupts normal cellular ionic balances promoting fluid and electrolyte movement into the intestinal lumen. The pathways involving LT-B closely link to proteins such as GM1 ganglioside and adenylate cyclase coordinating to amplify the effects of the enterotoxin A subunit in signal transduction.

LT-B significantly contributes to conditions like traveler's diarrhea and other infections caused by enterotoxigenic Escherichia coli (ETEC). The B subunit's mediative properties of cell entry are important for these pathologies exacerbating the symptoms by enhancing toxin delivery and action. In the context of its involvement in disease the interaction with the A chain is fundamental as the A subunit's enzymatic activity results in the pathological hypersecretion observed in cases of ETEC infection.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

This enterotoxin is responsible for many cases of a mild type of food poisoning.
See full target information Heat-labile enterotoxin B chain
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Microbiology spectrum 11:e0152523 PubMed37916813

2023

ArcA positively regulates the expression of virulence genes and contributes to virulence of porcine Shiga toxin-producing enterotoxigenic .

Applications

Unspecified application

Species

Unspecified reactive species

Fengwei Jiang,Yan Yang,Zhao Mao,Wentong Cai,Ganwu Li
제품이 사용된 논문 모두 보기
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Product promise

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