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AB187529

Anti-Hemojuvelin antibody

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(1 출판물)

Rabbit Polyclonal Hemojuvelin antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HJV.

대체 명칭 보기

HFE2, RGMC, HJV, Hemojuvelin, Hemochromatosis type 2 protein, Hemojuvelin BMP coreceptor, RGM domain family member C

1 이미지
Western blot - Anti-Hemojuvelin antibody (AB187529)
  • WB

Supplier Data

Western blot - Anti-Hemojuvelin antibody (AB187529)

All lanes:

Western blot - Anti-Hemojuvelin antibody (ab187529) at 1/500 dilution

Lane 1:

HeLa cell extract

Lane 2:

PC3 cell extract

Predicted band size: 45 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human HJV.

Q6ZVN8

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대체품

Primary Antibodies

AB239591

Anti-Hemojuvelin antibody [C1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C1] (AB239591)

  • 0
  • 0
Primary Antibodies

AB239492

Anti-Hemojuvelin antibody [A7]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [A7] (AB239492)

  • 0
  • 0
Primary Antibodies

AB239495

Anti-Hemojuvelin antibody [C6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C6] (AB239495)

  • 0
  • 0

보완 제품

Assay Kits

AB243685

Mouse RGM-C ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Mouse RGM-C ELISA Kit (AB243685)

  • 0
  • 0
Primary Antibodies

AB281583

Anti-CD31 antibody [RM1006]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [RM1006] (AB281583)

  • 5
  • 5
Primary Antibodies

AB14714

Anti-SDHB antibody [21A11AE7]

KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-SDHB antibody [21A11AE7] (AB14714)

  • 5
  • 12
Primary Antibodies

AB110271

Anti-MTCO2 antibody [4B12A5]

Western blot - Anti-MTCO2 antibody [4B12A5] (AB110271)

  • 1
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Hemojuvelin also known as HJV or RGMc is a glycosylphosphatidylinositol-anchored protein that plays a significant role in iron homeostasis. It has a molecular mass of about 42 kDa. Expression of hemojuvelin is mainly observed in the liver heart and skeletal muscles. This protein is essential for maintaining systemic iron levels and regulates how much iron is absorbed and stored in the body.
Biological function summary

Hemojuvelin interacts with other proteins to modulate iron metabolism. It acts as a coreceptor for bone morphogenetic proteins (BMPs) enhancing BMP signaling which is critical in regulating the peptide hormone hepcidin. Hemojuvelin itself is not part of a larger complex but it works closely with BMPs to control hepcidin expression. Hepcidin is the key hormone that dictates iron absorption and its release from macrophages maintaining iron balance.

Pathways

Hemojuvelin functions primarily within the BMP signaling and hepcidin regulatory pathways. The interaction with BMP6 is particularly critical. The BMP6-hemojuvelin complex boosts the SMAD signaling cascade resulting in increased hepcidin expression. This cascade impacts iron levels in the body by limiting intestinal iron absorption and controlling iron recycling by macrophages.

Hemojuvelin mutations can lead to juvenile hemochromatosis a condition characterized by excessive iron buildup in the body. This protein's dysfunction can severely affect iron homeostasis leading to detrimental health outcomes. Moreover its connection to the regulation of hepcidin links hemojuvelin to conditions like anemia of chronic disease where hepcidin expression is aberrantly increased or decreased. Understanding the interaction of hemojuvelin and hepcidin provides insights into the mechanisms behind these iron-related disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed : 18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed : 18976966).
See full target information HJV
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nucleic acids research 51:6337-6354 PubMed37224534

2023

Actin nucleators safeguard replication forks by limiting nascent strand degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Jadwiga Nieminuszczy,Peter R Martin,Ronan Broderick,Joanna Krwawicz,Alexandra Kanellou,Camelia Mocanu,Vicky Bousgouni,Charlotte Smith,Kuo-Kuang Wen,Beth L Woodward,Chris Bakal,Fiona Shackley,Andrés Aguilera,Grant S Stewart,Yatin M Vyas,Wojciech Niedzwiedz
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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