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AB234979

Anti-HEXIM2 antibody

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Rabbit Polyclonal HEXIM2 antibody. Suitable for WB, IHC-P and reacts with Rat, Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HEXIM2.

대체 명칭 보기

L3, HEXIM2, Protein HEXIM2, Hexamethylene bis-acetamide-inducible protein 2

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEXIM2 antibody (AB234979)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEXIM2 antibody (AB234979)

Paraffin-embedded human testis tissue stained for HEXIM2 with ab234979 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human HEXIM2.

Q96MH2

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대체품

Primary Antibodies

AB127710

Anti-HEXIM2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-HEXIM2 antibody (AB127710)

  • 0
  • 0

보완 제품

Primary Antibodies

AB184703

Anti-Cyclin T1 antibody [EPR17982]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Cyclin T1 antibody [EPR17982] (AB184703)

  • 3
  • 1
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
Primary Antibodies

AB240647

Anti-HEXIM1 antibody [EPR23430-12] - ChIP Grade

BOND RX™ Validated|RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEXIM1 antibody [EPR23430-12] - ChIP Grade (AB240647)

  • 0
  • 0
Primary Antibodies

AB196436

Anti-MLKL (phospho S345) antibody [EPR9515(2)]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-MLKL (phospho S345) antibody [EPR9515(2)] (AB196436)

  • 4
  • 27
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

HEXIM2 also known as Hexamethylene Bisacetamide-Inducible Protein 2 is a protein with a molecular mass of approximately 36 kDa. It functions as a regulatory protein with roles in transcription modulation. HEXIM2 is expressed in various human tissues with notable expression levels in the heart and skeletal muscle. This protein acts as a part of the regulation network that interacts with RNA polymerase II during the transcription process.
Biological function summary

HEXIM2 plays a role in the inhibitory regulation of transcription. It forms part of the 7SK small nuclear ribonucleoprotein (snRNP) complex which is known for controlling the activity of the positive transcription elongation factor b (P-TEFb). This complex regulates RNA polymerase II by inhibiting its transcriptional elongation capability therefore controlling gene expression. The presence of HEXIM2 in this complex indicates its involvement in modulating gene expression through RNA interference pathways.

Pathways

HEXIM2 operates within the transcription elongation regulation pathway and the cell cycle control pathway. In the transcription elongation regulation pathway it contributes significantly to the inhibition of P-TEFb which associates with Cyclin T1 and CDK9. These proteins are vital for allowing RNA polymerase II to proceed with transcription. HEXIM2's involvement ensures the proper timing and modulation of transcriptional activities controlling cellular functions and responses.

HEXIM2 has associations with cancer and cardiac-related conditions. Its role in transcription regulation links it to various forms of cancer where aberrant gene expression is a hallmark. Additionally HEXIM2's expression in cardiac tissues suggests implications in cardiac disorders. Interactions with proteins like Cyclin T1 and CDK9 which are also involved in these conditions highlight potential pathways where HEXIM2 might contribute to disease progression or resistance mechanisms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed : 15713661, PubMed : 15713662). Core component of the 7SK RNP complex : in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed : 15713661, PubMed : 15713662).
See full target information HEXIM2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2416590 PubMed40298908

2025

Nuclear-Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Haiying Liu,Jiaqian Feng,Tingting Pan,Pinggen Zhang,Ling Ye,Zetan Jiang,Zilong Zhou,Qiankun Mao,Jian Li,Xinyi Yang,Ping Gao,De Huang,Huafeng Zhang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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