AB216623

Anti-HGF antibody

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(6 제품이 사용된 논문 )

Rabbit Polyclonal HGF antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human HGF aa 200-300 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

HPTA, HGF, Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HGF antibody (AB216623)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HGF antibody (AB216623)

Immunohistochemical analysis of formalin-fixed paraffin-embedded rat kidney tissue, labeling HGF using ab216623 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human HGF aa 200-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P14210

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대체품

Primary Antibodies

AB10829

Anti-HGF antibody [EGH2 4C12.1]

Sandwich ELISA - Anti-HGF antibody [EGH2 4C12.1] (AB10829)

Primary Antibodies

AB24865

Anti-HGF antibody

Sandwich ELISA - Anti-HGF antibody (AB24865)

Primary Antibodies

AB178395

Anti-HGF antibody [EPR12230]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-HGF antibody [EPR12230] (AB178395)

Primary Antibodies

AB240204

Anti-HGF antibody [EPR12230] - BSA and Azide free

RabMAb|Recombinant

Immunoprecipitation - Anti-HGF antibody [EPR12230] - BSA and Azide free (AB240204)

Primary Antibodies

AB118871

Anti-HGF antibody [7-2]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HGF antibody [7-2] (AB118871)

보완 제품

Assay Kits

AB275901

Human HGF ELISA Kit (Hepatocyte Growth Factor)

Recombinant|SimpleStep

ELISA - Human HGF ELISA Kit (Hepatocyte Growth Factor) (AB275901)

Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

Primary Antibodies

AB51067

Anti-Met (c-Met) antibody [EP1454Y] - N-terminal

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-Met (c-Met) antibody [EP1454Y] - N-terminal (AB51067)

Primary Antibodies

AB76011

Anti-N Cadherin antibody [EPR1791-4]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-N Cadherin antibody [EPR1791-4] (AB76011)

Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The hepatocyte growth factor (HGF) also known as scatter factor (SF) is a protein with a mass of approximately 83 kDa. This protein is mostly expressed in the liver but it can also be found in other organs such as the kidney and the lungs. HGF acts mechanically by binding to the c-Met receptor activating intracellular signaling mechanisms necessary for various physiological processes. Researchers often use HGF ELISA kits to measure its levels in biological samples and study its various roles.

Biological function summary

HGF plays an essential role in cellular growth regeneration and healing processes across different tissues. It is not part of a complex but functions as a single-chain polypeptide that undergoes cleavage into its active form. HGF facilitates cell proliferation and migration; this is especially important during organ regeneration and repair processes. By engaging with its receptor c-Met it induces cell survival and cytoskeletal reorganization making it important for wound healing.

Pathways

HGF is critical in the MAPK and PI3K-Akt signaling pathways which impact processes like cell division and survival. Through these pathways HGF interacts with other proteins such as ERK and Akt contributing to the regulation of cellular growth and metabolism. HGF's role in these pathways highlights its importance in developmental processes and tissue homeostasis.

HGF displays significant connections to cancer and liver cirrhosis. Its overexpression can lead to the development of various carcinomas due to its effect on cell proliferation and migration. In liver cirrhosis the altered HGF-c-Met signaling might contribute to the disease progression and hepatic dysfunction. Additionally HGF can interact with proteins such as transforming growth factor-beta (TGF-β) in these conditions influencing the pathological environment.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed : 20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed : 15167892, PubMed : 20977675). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed : 20977675).

See full target information HGF

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제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

World journal of experimental medicine 15:102897 PubMed40546670

2025

Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both and models.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Terasawa,Kazuhiro Shimazu,Hiroshi Nanjo,Masatomo Miura,Hiroyuki Shibata

BMC pediatrics 25:288 PubMed40221697

2025

Gene proteins, growth factors/their receptors in the wall of chronic calculous cholecystitis-affected gallbladder children.

Applications

Unspecified application

Species

Unspecified reactive species

Darja Derbeneva,Mara Pilmane,Aigars Petersons

Journal of cellular and molecular medicine 28:e70098 PubMed39307884

2024

Inhibition of circular JUN prevents the proliferation and invasion of glioblastoma via miR-3064-IGFBP5 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuhao Zhang,Shiming Liu,Cheng Wu,Xin Gao,Hongtao Zhao,Ou Li,Faliang Gao

Journal of personalized medicine 12: PubMed36556214

2022

AXL and MET Tyrosine Kinase Receptors Co-Expression as a Potential Therapeutic Target in Malignant Pleural Mesothelioma.

Applications

Unspecified application

Species

Unspecified reactive species

Federica Zito Marino,Carminia Maria Della Corte,Vincenza Ciaramella,Stefania Erra,Andrea Ronchi,Alfonso Fiorelli,Giovanni Vicidomini,Mario Santini,Giosuè Scognamiglio,Floriana Morgillo,Fortunato Ciardiello,Renato Franco,Marina Accardo

Cells 10: PubMed34831042

2021

Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation.

Applications

Unspecified application

Species

Unspecified reactive species

Nesrine Ebrahim,Omnia A M Badr,Mohamed M Yousef,Amira Hassouna,Dina Sabry,Ayman Samir Farid,Ola Mostafa,Hajir A Al Saihati,Yasmin Seleem,Eman Abd El Aziz,Ahmed Hassan Khalil,Ahmed Nawar,Ahmed A Shoulah,Mohammad Aljasir,Amira Zaki Mohamed,Mohamed El-Sherbiny,Nehal M Elsherbiny,Mohamed Ahmed Eladl,Nicholas Robert Forsyth,Rabab F Salim

Evidence-based complementary and alternative medicine : eCAM 2021:5574555 PubMed34408780

2021

Curcumin Inhibits HGF-Induced EMT by Regulating c-MET-Dependent PI3K/Akt/mTOR Signaling Pathways in Meningioma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaodong Chen,Fen Tian,Peng Lun,Yugong Feng

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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