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AB69565

Anti-HIPK4 antibody

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(1 출판물)

Rabbit Polyclonal HIPK4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HIPK4.
3 이미지
Immunocytochemistry/ Immunofluorescence - Anti-HIPK4 antibody (AB69565)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-HIPK4 antibody (AB69565)

Immunofluorescence analysis of A549 cells, using 1 : 500 ab69565. For the right hand image, the antibody was pre-incubated with the immunizing peptide.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HIPK4 antibody (AB69565)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HIPK4 antibody (AB69565)

Immunohistochemistry analysis of paraffin-embedded human testis tissue using 1 : 50 ab69565. For the right hand image the antibody was pre-incubated with the immunizing peptide.

Western blot - Anti-HIPK4 antibody (AB69565)
  • WB

Unknown

Western blot - Anti-HIPK4 antibody (AB69565)

All lanes:

Western blot - Anti-HIPK4 antibody (ab69565) at 1/500 dilution

Lane 1:

extracts from HUVEC cells at 30 µg

Lane 2:

extracts from HUVEC cells at 30 µg with immunizing peptide

Predicted band size: 69 kDa

Observed band size: 69 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human HIPK4. The exact immunogen used to generate this antibody is proprietary information.

Q8NE63

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보완 제품

Primary Antibodies

AB124762

Anti-p63 antibody [EPR5701]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p63 antibody [EPR5701] (AB124762)

  • 4
  • 13
Primary Antibodies

AB92581

Anti-p63 (phospho S395) antibody

Western blot - Anti-p63 (phospho S395) antibody (AB92581)

  • 0
  • 0
Primary Antibodies

AB197372

Anti-RAMP3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAMP3 antibody (AB197372)

  • 0
  • 0
Primary Antibodies

AB247172

Anti-EPPK1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EPPK1 antibody (AB247172)

  • 4
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

HIPK4 known as Homeodomain Interacting Protein Kinase 4 acts as a serine/threonine-protein kinase. It weighs around 69 kDa. This protein primarily localizes in the nucleus and occasionally the cytoplasm across various tissues. HIPK4 participates in phosphorylation processes modifying the activity of multiple substrates. Researchers often study it for its potential interactions with different transcription factors and regulators.
Biological function summary

This protein plays an important role in regulating cell growth and differentiation. HIPK4 does not function as part of a complex but acts independently to impact these cellular processes. It can influence the expression of genes involved in apoptosis and cell cycle regulation indicating its significant influence on cellular homeostasis.

Pathways

Researchers recognize HIPK4's involvement in the Wnt signaling and JNK pathways. The protein interacts with other kinases such as HIPK2 which also play roles in these pathways. These interactions suggest that HIPK4 might have diverse biological effects including those on development and cancer evolution.

Scientists have linked HIPK4 to cancer and neurodegenerative diseases. It interacts with proteins like p53 which are important in tumor suppression. HIPK4's alteration may contribute to the development of cancer by disturbing the balance of cell proliferation and death. Additionally its dysregulation could potentially connect to neuronal cell death implicating a role in neurodegenerative conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).
See full target information HIPK4

대체 명칭 보기

Homeodomain-interacting protein kinase 4, HIPK4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports 42:112633 PubMed37314927

2023

Phosphatidylinositol 4-kinase IIα is a glycogen synthase kinase 3-regulated interaction hub for activity-dependent bulk endocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Eva-Maria Blumrich,Jessica C Nicholson-Fish,Marie Pronot,Elizabeth C Davenport,Dominic Kurian,Adam Cole,Karen J Smillie,Michael A Cousin
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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