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AB5103

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody

Anti-Histone H3 (citrulline R2 + R8 + R17) 항체

4

(28 리뷰들)

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(861 제품이 사용된 논문 )

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) is a rabbit polyclonal antibody detecting Histone H3 in Western Blot, IP, PepArr. Suitable for Human, Mouse, Rat.

- Over 590 publications
- Trusted since 2004
7 이미지
Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)
  • WB

Lab

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

Loading Control : GAPDH

This blot was produced using a 4-12% Bis-tris gel under the MES buffer system. The gel was run at 200V for 35 minutes before being transferred onto a Nitrocellulose membrane at 30V for 70 minutes. The membrane was then blocked for an hour using Licor blocking buffer before being incubated with ab5103 overnight at 4°C. Antibody binding was detected using Goat anti Rabbit IR680 secondary at a 1 : 10,000 dilution for 1hr at room temperature and then imaged using the Licor Odyssey CLx.

All lanes:

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) at 0.2 µg/mL

Lane 1:

HL60 whole cell lysate (negative control) at 20 µg

Lane 2:

HL60 whole cell lysate + DMSO (solvent control) at 20 µg

Lane 3:

HL60 whole cell lysate + DMSO + Calcium Ionophore (positive control) at 20 µg

Secondary

All lanes:

Goat anti Rabbit IR680 at 1/10000 dilution

Predicted band size: 15 kDa

Observed band size: 17 kDa

false

Immunoprecipitation - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)
  • IP

Supplier Data

Immunoprecipitation - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

This immunoprecipitation image is a comparison between ab5103 and the alternative recombinant multiclonal antibody ab281584.

Left side - Recombinant multiclonal to Histone H3 (citrulline R2 + R8 + R17) - ab281584
All lanes : Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001] ab281584 at 1/1000 dilution.
Lane 1 : HEK-293T (human embryonic kidney) transfected with PADI4 expression vector containing a GFP-tag treated with 10 mM calcium chloride and 10 μM lonomycin for 4 hours, whole cell lysate 10 μg.
Lane 2 : ab281584 IP in HEK-293T transfected with PADI4 expression vector containing a GFP-tag treated with 10 mM calcium chloride and 10 μM lonomycin for 4 hours whole cell lysate
Lane 3 : Rabbit monoclonal IgG (ab172730) instead of ab281584 in HEK-293T transfected with PADI4 expression vector containing a GFP-tag treated with 10 mM calcium chloride and 10 μM lonomycin for 4 hours whole cell lysate

Right side : Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103)
All lanes : Anti-Histone H3 (citrulline R2 + R8 + R17) antibody ab5103 at 1/1000 dilution.
Lane 1 : HEK-293T (human embryonic kidney) transfected with PADI4 expression vector containing a GFP-tag treated with 10 mM calcium chloride and 10 μM lonomycin for 4 hours, whole cell lysate 10 μg.
Lane 2 : ab5103 IP in HEK-293T transfected with PADI4 expression vector containing a GFP-tag treated with 10 mM calcium chloride and 10 μM lonomycin for 4 hours whole cell lysate
Lane 3 : Rabbit monoclonal IgG (ab172730) instead of ab5103 in HEK-293T transfected with PADI4 expression vector containing a GFP-tag treated with 10 mM calcium chloride and 10 μM lonomycin for 4 hours whole cell lysate

Secondary
All lanes : VeriBlot for IP Detection Reagent (HRP)(ab131366) was used at 1/5000 dilution.

Predicted band size : 15kDa

Why choose a recombinant antibody?
Research with confidence – consistent and reproducible results with every batch
Long-term and scalable supply – powered by recombinant technology for fast production
Success from the first experiment – confirmed specificity through extensive validation
Ethical standards compliant – production is animal-free

All lanes:

Immunoprecipitation - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103)

Predicted band size: 15 kDa

false

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)
  • WB

Lab

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

Abcam recommends using milk as the blocking agent. Abcam welcomes customer feedback and would appreciate any comments regarding this product and the data presented above.

Blots were developled with Goat Anti-Rabbit IgG H&L (HRP) (ab97051) secondary antibody

All lanes:

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) at 1 µg/mL

All lanes:

HL60 (Human Caucasian promyelocytic leukaemia) DMSO and Calcium Ionophore treated Whole Cell Lysate at 10 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/ko/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/10000 dilution

Predicted band size: 15 kDa

Observed band size: 17 kDa

true

Exposure time: 30s

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)
  • WB

Supplier Data

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

This western blot image is a comparison between ab5103 and the alternative recombinant multiclonal antibody ab281584.

Left side - Recombinant multiclonal to Histone H3 (citrulline R2 + R8 + R17) - ab281584
All lanes : Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001] ab281584 at 1/1000 dilution.
Lane 1 : Untreated HEK-293T (human embryonic kidney) transfected with PADI4 expression vector containing a myc-His-tag®, whole cell lysate
Lane 2 : HEK-293T transfected with PADI4 expression vector containing a myc-His-tag® treated with 10 mM calcium chloride and 10 μM lonomycin for 4 hours, whole cell lysate
Lane 3 : Untreated NIH/3T3 (mouse embryonic fibroblast) transfected with PADI4 expression vector containing a myc-His-tag®, whole cell lysate
Lane 4 : NIH/3T3 transfected with PADI4 expression vector containing a myc-His-tag® treated with 10 mM calcium chloride and 10 μM lonomycin for 4 hours, whole cell lysate

Right side : Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103)
All lanes : Anti-Histone H3 (citrulline R2 + R8 + R17) antibody ab5103 at 1/1000 dilution.
Lane 1 : Untreated HEK-293T (human embryonic kidney) transfected with PADI4 expression vector containing a myc-His-tag®, whole cell lysate
Lane 2 : HEK-293T transfected with PADI4 expression vector containing a myc-His-tag® treated with 10 mM calcium chloride and 10 μM lonomycin for 4 hours, whole cell lysate
Lane 3 : Untreated NIH/3T3 (mouse embryonic fibroblast) transfected with PADI4 expression vector containing a myc-His-tag®, whole cell lysate
Lane 4 : NIH/3T3 transfected with PADI4 expression vector containing a myc-His-tag® treated with 10 mM calcium chloride and 10 μM lonomycin for 4 hours, whole cell lysate

Lysates/proteins at 20 μg per lane.

Secondary
All lanes : Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/100000 dilution (Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated)

Why choose a recombinant antibody?
Research with confidence – consistent and reproducible results with every batch
Long-term and scalable supply – powered by recombinant technology for fast production
Success from the first experiment – confirmed specificity through extensive validation
Ethical standards compliant – production is animal-free

All lanes:

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103)

Predicted band size: 15 kDa

false

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)
  • WB

Unknown

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

Blocking buffer : 2% BSA

Gel type : MES

All lanes:

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) at 1 µg/mL

Lane 1:

Mouse brain tissue lysate at 10 µg

Lane 2:

Rat brain tissue lysate at 10 µg

Secondary

All lanes:

Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/50000 dilution

Predicted band size: 15 kDa

Observed band size: 17 kDa

false

Exposure time: 1min

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)
  • WB

Unknown

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

Blocking buffer : 2% BSA

Gel type : MES

All lanes:

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) at 1 µg/mL

Lane 1:

NIH/3T3 (Mouse embryo fibroblast cell line) nuclear lysate at 10 µg

Lane 2:

PC12 (Rat adrenal pheochromocytoma cell line) nuclear lysate at 10 µg

Secondary

All lanes:

Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/50000 dilution

Predicted band size: 15 kDa

Observed band size: 17 kDa

false

Exposure time: 1min

Peptide Array - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)
  • PepArr

Lab

Peptide Array - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

All batches of ab5103 are tested in Peptide Array against peptides to different Histone H3 modifications. Six dilutions of each peptide are printed on to the Peptide Array in triplicate and results are averaged before being plotted on to a graph. Results show strong binding to Histone H3 - citrulline 2 + 8 + 17 peptide (ab32876), indicating that this antibody specifically recognises the Histone H3 - citrulline 2 + 8 + 17 modifications.

ab32876 - Histone H3 - citrulline 2 + 8 + 17

ab17566 - Histone H3 - unmodified

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

PepArr, WB, IP

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

<p>In peptide array this product recognises the Histone H3 (citrulline R2+R8+R17&#41; peptide and shows minimal crossreactivity with the nonmodified peptide.<br><br>Treatment is required for detection of the target protein. See Protocol section for detailed information. 更多详细信息请参阅 Protocol 部分.</p>

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "PepArr" : {"fullname" : "Peptide Array", "shortname":"PepArr"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p><strong>In our hands, when tested in western blot, this product typically gives a weaker signal in mouse and rat tissue lysates compared to mouse and rat cell lines. Abcam welcomes customer feedback and would appreciate any comments regarding this product and the data presented above.</strong></p><p>Abcam recommends using 3-5% milk as the blocking agent</p><p>We recommend Goat Anti-Rabbit IgG H&amp;L (HRP) (<a href='/ko/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) secondary antibody.</p>", "PepArr-species-checked": "guaranteed", "PepArr-species-dilution-info": "", "PepArr-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p><strong>In our hands, when tested in western blot, this product typically gives a weaker signal in mouse and rat tissue lysates compared to mouse and rat cell lines. Abcam welcomes customer feedback and would appreciate any comments regarding this product and the data presented above.</strong></p><p>Abcam recommends using 3-5% milk as the blocking agent</p><p>We recommend Goat Anti-Rabbit IgG H&amp;L (HRP) (<a href='/ko/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) secondary antibody.</p>", "PepArr-species-checked": "guaranteed", "PepArr-species-dilution-info": "", "PepArr-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p><strong>In our hands, when tested in western blot, this product typically gives a weaker signal in mouse and rat tissue lysates compared to mouse and rat cell lines. Abcam welcomes customer feedback and would appreciate any comments regarding this product and the data presented above.</strong></p><p>Abcam recommends using 3-5% milk as the blocking agent</p><p>We recommend Goat Anti-Rabbit IgG H&amp;L (HRP) (<a href='/ko/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) secondary antibody.</p>", "PepArr-species-checked": "guaranteed", "PepArr-species-dilution-info": "", "PepArr-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "PepArr-species-checked": "predicted", "PepArr-species-dilution-info": "", "PepArr-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "PepArr-species-checked": "predicted", "PepArr-species-dilution-info": "", "PepArr-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "PepArr-species-checked": "predicted", "PepArr-species-dilution-info": "", "PepArr-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Recombinant fragment - Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "1/1000", "IP-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "PepArr-species-checked": "notRecommended", "PepArr-species-dilution-info": "", "PepArr-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Synthetic peptide": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "PepArr-species-checked": "testedAndGuaranteed", "PepArr-species-dilution-info": "", "PepArr-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

제품 세부 정보

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) is a rabbit polyclonal antibody and is validated for use in IP, PepArr and WB.

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) was first used in a scientific publication in 2004 and has been cited over 595 times in peer reviewed journals.

Abcam's high quality validation processes ensure Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) has high sensitivity and specificity.

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) has 27 independent reviews from customers.

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) specifically detects Histone H3 Citrulline-R2, Citrulline-R8, Citrulline-R17 (UniProt ID: P68431; Molecular weight: 16kDa) and is sold in 100 µg selling sizes.

Top cited antibody for this target with >800 citations. This antibody is a key tool in cancer research, particularly in understanding histone citrullination's role in tumorigenesis and is widely used in studies of gene expression, DNA repair and autoimmune diseases like rheumatoid arthritis and lupus, involving protein arginine deiminases (PADs) and NETosis. Histone hypercitrullination is reported to play a role the progression of various cancers, including multiple myeloma, acute myeloid leukaemia, lung cancer and hepatocellular carcinoma.

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
Treatment Conditions:

Chemical treatment is required for detection of endogenous citrullinated proteins in cell lines. PADs (including PADI2 and PADI4) are the enzymes that hydrolyze arginine to citrulline, in the presence of Ca2+ and ionomycin. Please refer to PMID: 26360112

Controls:
- Mock (no transfection)
- Transfection reagent–only control
- Empty vector control
- Vehicle control for chemical treatment

Generation of PADI2 or PADI4 overexpression cell line and treatment with CaCl2/Ionomycin:

1. Prior to transfection with PADI2 or PADI4 expression vector, seed cells in complete medium and place in a 37°C, 5% CO2 incubator for 24 hours or until cells reach 70-80% confluence.

For a single T-175 flask we recommend seeding the following common cell lines as follows in 30 mL media:
- HEK-293T: 1x107 cells
- MCF7: 2.5-4x106 cells
- NIH3T3: 4-5x106 cells
- C6: 3-4x106 cells

2. Once cells have reached confluence, prepare the PADI2 or PADI4 expression vector for transfection using your preferred method (PMID: 33976969).
3. 24-48 hours after transfection, remove the medium from the cells and replace with fresh complete medium containing 10 mM CaCl2 (ab285384) and 10 uM Ionomycin (ab120116) and incubate for 2-4 hours.

Key Considerations:
For alternative cell lines, you should confirm the transfectability, growth rate, and sensitivity of the cell line to the planned chemical treatment. Incubation times and treatment length may need to be adjusted.

Western Blot Conditions:
Recommended SDS-PAGE Gel Type: 4-12% Bis-Tris
Recommended Running Buffer: MES
Primary: 1/1000 dilution at 4°C overnight or room temperature for 1 hour
Blocking: 5% NFDM at room temperature for 1 hour

Positive Control: Cell line overexpressing PADI4 and treated with CaCl2/Ionomycin
Negative Control: Cell line overexpressing PADI4

Additional resources:
Lysate preparation protocol
Lysate preparation protocol - nuclear proteins
Lysate preparation protocol - low molecular weight proteins
Western blot troubleshooting

타겟 정보

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
See full target information H3C1 citrulline R2

대체 명칭 보기

H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J, H3C1, H3FC, HIST1H3C, Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, H3R2cit

제품이 사용된 논문 (861)

Recent publications for all applications. Explore the 전체 목록and refine your search

Journal of translational medicine 23:1074 PubMed41074088

2025

Proteomic insights into platelet dysregulation and pathogenic mechanisms of chronic thromboembolic pulmonary hypertension.

Applications

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Species

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Lu Sun,Haobo Li,Yuhan Li,Xincheng Li,Han Tian,Jixiang Liu,Min Liu,Jinzhi Wang,Qiang Huang,Zhu Zhang,Xiaofan Ji,Linfeng Xi,Kuangxun Li,Yishan Li,Ximei Niu,Mengjie Duo,Bingzhang Zou,Jing Wen,Jie Li,Ran Miao,Wanmu Xie,Shiqing Xu,Peiran Yang,Zhenguo Zhai

Nature communications 16:8870 PubMed41053178

2025

Paraventricular nucleus CRH neurons regulate acute lung injury via sympathetic nerve-neutrophil axis.

Applications

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Species

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Hui Li,Tao Liu,Yang Wang,Xue-Mei Miao,Yi-Yu Xiong,Qian Zhao,Wei-Yun Shen,Fu-Hong Su,Kang Chen,Ru-Ping Dai

Journal of immunology research 2025:8039031 PubMed41031144

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The Dynamic Expression Changes of Neutrophil Extracellular Traps in Mouse Apical Periodontitis: A Potential Correlation With IL-17.

Applications

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Species

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Zihan Ma,Xiaoyue Sun,Ying Lin,Zijun Wang,Qing Nie,Jingjing Yu,Jingwen Yang,Lingxin Zhu

iScience 28:113485 PubMed41019372

2025

Comparative effects of hemodialysis modalities on microparticle induction and neutrophil activation in a randomized cross-over study.

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Species

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Awirut Charoensappakit,Jirarat Eiamcharoenying,Kritsanawan Sae-Khow,Suwasin Udomkarnjananun,Khajohn Tiranathanagul,Asada Leelahavanichkul

International journal of molecular sciences 26: PubMed41009700

2025

An Expendable Player in Positive Vascular Remodeling? ADAMTS13 Deficiency Does Not Affect Arteriogenesis or Angiogenesis.

Applications

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Species

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Carolin Baur,Amanda Geml,Kira-Sofie Wimmer,Franziska Heim,Anja Holschbach,Katharina Elbs,Michael R Rohrmoser,Dominic van den Heuvel,Alexander T Bauer,Stefan W Schneider,Daphne Merkus,Elisabeth Deindl

The Journal of experimental medicine 222: PubMed40986319

2025

Type I IFN drives neutrophil swarming, impeding lung T cell-macrophage interactions and TB control.

Applications

Unspecified application

Species

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William J Branchett,Evangelos Stavropoulos,Jessica Shields,Alaa Al-Dibouni,Marcos Cardoso,Ana Isabel Fernandes,Lúcia Moreira-Teixeira,Hubert Slawinski,Anna Mikolajczak,Angela Rodgers,Margarida Saraiva,Anne O'Garra

Frontiers in immunology 16:1651085 PubMed40963601

2025

The role of neutrophils and NETosis in lipopolysaccharide exacerbated asthmatic airway inflammation.

Applications

Unspecified application

Species

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Qian Qian,Qianye Zhao,Yongji Qian,Huan Deng,Xiaoming Feng,Jiamin Zhang,Xia Huang,Yi Du,Deyu Zhao,Feng Liu

Nature 647:747-756 PubMed40963017

2025

Myeloperoxidase transforms chromatin into neutrophil extracellular traps.

Applications

Unspecified application

Species

Unspecified reactive species

Garth Lawrence Burn,Tobias Raisch,Sebastian Tacke,Moritz Winkler,Daniel Prumbaum,Stephanie Thee,Niclas Gimber,Stefan Raunser,Arturo Zychlinsky

Theranostics 15:9221-9239 PubMed40963908

2025

Neutrophil extracellular traps induce endothelial damage and exacerbate vasospasm in traumatic brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Jinchao Wang,Lei Li,Jianye Xu,Dilmurat Gheyret,Kaiji Li,Xu Zhang,Haoran Jia,Ye Tian,Xiao Liu,Shenghui Li,Guili Yang,Yalong Gao,Ruilong Peng,Huajie Liu,Bin Liu,Jianfeng Zhuang,Cong Wang,Xin Chen,Yafan Liu,Bo Chen,Chuan Huang,Yuhan Li,Xin Chen,Jianning Zhang,Shu Zhang

PloS one 20:e0330864 PubMed40929060

2025

Peptidylarginine deiminase 4 deficiency alleviates hypoxia/reoxygenation-induced cardiomyocyte injury.

Applications

Unspecified application

Species

Unspecified reactive species

Matthias Mand,Michelle Holthaus,Helmut R Lieder,Petra Kleinbongard,Lenard Conradi,Thorsten Wahlers,Adnana Paunel-Görgülü
제품이 사용된 논문 모두 보기

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