Anti-HIV protease antibody [1696]

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This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

HIV protease is essential for the production of functional viral proteins facilitating viral particle assembly. It is not part of a larger complex but acts on its own to ensure correct protein maturation. Without the activity of this protease the virus cannot replicate efficiently as it fails to produce infectious viral particles. This makes HIV protease an ideal target for antiretroviral drugs which aim to inhibit its function and hinder the progression of the virus.

Pathways

The HIV protease plays a core role in the viral replication and maturation pathway essential for generating infectious virions. It interacts directly with the gag and gag-pol polyprotein precursors cleaving them into functional units necessary for structural components and replication machinery of the virus. Besides its action upon these precursor proteins integrates it tightly into the intricate machinery of HIV's lifecycle ensuring that all viral components become functionally active for subsequent infections.