Anti-HIV2 gp36 antibody [3B10/G2]

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Biological function summary

Gp36 of HIV impacts virus-host interactions by mediating the fusion between the viral envelope and the target cell membrane. This protein forms part of the envelope glycoprotein complex which includes other proteins such as gp105. Through interactions with cellular receptors gp36 aids in the initial stages of infection by enabling viral entry into host cells. This interaction characterizes its important function in the pathogenesis and life cycle of HIV-2.

Pathways

The gp 36 HIV protein is indispensable in the viral entry pathway of HIV-2. This pathway involves binding to CD4 receptors and coreceptors such as CCR5 or CXCR4 on the surface of host cells enabling the fusion process to occur. By associating with gp41 a homologous protein in HIV-1 gp36 is pivotal in facilitating this binding and fusion mechanism necessary for successful infection. The interaction between gp36 and these receptors signifies its integration and operation within a critical biological process required for viral entry.